Serum Ferritin and Soluble Transferrin Receptors in Type II Diabetic Patients: Correlation with TNF-αas a Marker of Inflammation | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 18, Volume 27, Issue 2, December 2007, Page 265-276 PDF (315.05 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37387 | ||||
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| Authors | ||||
| Amira Hassouna* 1; Ebtesam Zakaria2; Nehal Hamdy2; Maha Rakha2 | ||||
| 1Department of Medical Biochemistry , Faculty of Medicine, Cairo University | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Cairo University | ||||
| Abstract | ||||
| Over the past years cumulating evidence has confirmed interlinking pathways connecting type II diabetes mellitus (DM) with an underlying inflammatory process. Furthermore, iron overload states have alsobeen directly linkedto the development of insulin resistance and type II diabetes. Serum ferritin as well as most of the biochemical markers for iron are affected by the acute phase response rendering the assessment of iron status in patients with inflammatory conditions somewhat challenging. So, the present study aimed to determine circulating levels of ferritin and soluble transferring receptor (sTFR) in type II diabetic patients as well as TNF-αas an inflammatory marker in order to evaluate whether serum ferritin reflects iron body stores or inflammation in diabetic patients. Thirty diabetic patients and 15 healthy control subjects were included in the study. Serum ferritin, sTFR and TNF-αlevels were measured by enzyme immunoassay.Serum iron and total iron binding capacity (TIBC) were determined by quantitative colorimetric determination. The results of the study showed that diabeticpatients have significantly higher serum ferritin levels than control subjects. However, no differences in sTFR levels were observed between both groups. A significant negative correlation between ferritin and sTFR levels was detected in control subjects but not in diabetic patients. Moreover, a significant positive correlation was found between levels of TNF-αand ferritin but not with sTFR levels in diabetic patients. Conclusion: Serum ferritin levels are increased in type II diabetic patients in correlation with the inflammatory marker TNF-αand in the absence of a reciprocal decrease of sTFR. These findings suggest that the elevated ferritin levels in type II diabetes are mainly as a result of inflammatory mechanisms rather than iron overload. | ||||
| Keywords | ||||
| ferritin; soluble transferrin receptor TNF-α; Type II diabetes | ||||
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