Effect of zinc sulphate on indomethacin Induced changes in gastric secretion and Ulceration in male albino rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 1, Volume 26, Issue 1, June 2006, Page 1-10 PDF (219.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2006.37418 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mohamed El Ficky* ; Fawzy Ashour; Magdy Ahmed | ||||
| Department of Physiology, Faculty of Medicine, Al Azher University | ||||
| Abstract | ||||
| In the present study the effect of zinc sulphate on indomethacin-induced changes in gastric secretion and ulceration was investigated. Fifty adult male albino rats were used in this work divided into five equal groups. The first (control) group was given intraperitoneal (i.p) distilled water. The second (indomethacin) group was given i.p indomethacin 25 mg /kg. The third, fourth and fifth groups were given i.p zinc sulphate 10, 20, and 40 mg/kg i.p twenty minutes before indomethacin administration. Indomethacin led to a significant decrease in the volume of gastric juice and acid output with a significant increase in the acid concentration and ulcer index as compared to control group. Pretreatment with various doses of zincsulphate led to dose-dependant decrease in the volume, acid concentration and acid output of gastric juice as well as the ulcer index, there was dose-dependant increase inthe ulcer prevention indices as compared with group of rats given indomethacin. Indomethacin showed microscopic great destructive effect on gastric mucosa, while zinc sulphate showed dose dependent improvement in the microscopic destructive effect of indomethacin. The anti-ulcer effect of zinc sulphate was attributed to decrease in gastric acid secretion, reduction in neutrophils infiltration with increase of mucus secretion and improvement of gastric mucosal blood flow. Zinc sulphate also showstabilizing effect on lysosomes with prevention of release of lysosomal enzymes and scavenging of oxygen-free radicals through its antioxidant effect. We can conclude that zinc sulphate has a better effect in prevention of indomethacin-inducedgastric ulceration and can be used as a prophylactic remedy in patients using non-steroidal anti-inflammatory drugs. | ||||
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