Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress
Abel-Gawad, H., Sultan, H., Francis, A., Hanafi, M. (2006). Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress. EKB Journal Management System, 26(1), 149-160. doi: 10.21608/besps.2006.37441
Hala Abel-Gawad; Hala Sultan; Ashraf Francis; Mervat Hanafi. "Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress". EKB Journal Management System, 26, 1, 2006, 149-160. doi: 10.21608/besps.2006.37441
Abel-Gawad, H., Sultan, H., Francis, A., Hanafi, M. (2006). 'Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress', EKB Journal Management System, 26(1), pp. 149-160. doi: 10.21608/besps.2006.37441
Abel-Gawad, H., Sultan, H., Francis, A., Hanafi, M. Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress. EKB Journal Management System, 2006; 26(1): 149-160. doi: 10.21608/besps.2006.37441

Study of the pathophysiologic role of tissue factorpathway inhibitor in modulating thalassemia induced hypercoagulable state:relationship to oxidative stress

Bulletin of Egyptian Society for Physiological Sciences
Article 12, Volume 26, Issue 1, June 2006, Page 149-160  XML PDF (188.91 K)
Document Type: Original Article
DOI: 10.21608/besps.2006.37441
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Authors
Hala Abel-Gawad* 1; Hala Sultan2; Ashraf Francis2; Mervat Hanafi3
1Physiology Department,Faculty of Medicine, University of Alexandria
2Hematology Department, Medical Research Institute, University of Alexandria
3Blood bank, Medical Research Institute, University of Alexandria
Abstract
In view of the improved care of thalassemic patients which resulted in doubling
of life expectancy, additional previously undescribed complications are now being
recognized.In particular, a chronic hypercoagulable state has been observed in these
patients, yet the actual mechanism of its production has not been fully elucidated. To
our knowledge, the tissue factor pathway and its inhibitor have not been studied in
thalassemics. The aim of the present work was to estimate tissue factor pathway
inhibitor (TFPI) relation to oxidative stress assessed by thiobarbituric acid reactive
substances (TBARS). Twenty patients with thalassemia major and ten healthy controls
were enrolled in the study. Complete blood picture, serum ferritin, screening tests for
coagulation, prothrombin and partial thromboplastin times(PT,PTT) and
prothrombin activity (P activity %) have been estimated. The mean TFPI was higher
in patients than controls but did not reach statistical significance, TBARS and serum
ferritin were significantly higher in patients than controls(p=0.000)reflecting the
presence of oxidative stress. No relation was found between TFPI and chelating agent
(desferrioxamine) intake, splenectomy or TBARS. In conclusion, tissue factor pathway
(TFP) as reflected by increased TFPI could be, at least in part incriminated in the
thalassemia-induced hypercoagulable state.
Keywords
thalassemia; Hypercoagulability; tissue factor pathway inhibitor; Oxidative Stress
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