Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten
SA, E., HF, F., AI, Y., MM, O., MY, E., NA, H. (2006). Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten. EKB Journal Management System, 26(2), 71-88. doi: 10.21608/besps.2006.37514
Ebied SA; Farag HF; Youssef AI; Ossman MM; EL-Samak MY; Hassnian NA. "Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten". EKB Journal Management System, 26, 2, 2006, 71-88. doi: 10.21608/besps.2006.37514
SA, E., HF, F., AI, Y., MM, O., MY, E., NA, H. (2006). 'Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten', EKB Journal Management System, 26(2), pp. 71-88. doi: 10.21608/besps.2006.37514
SA, E., HF, F., AI, Y., MM, O., MY, E., NA, H. Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten. EKB Journal Management System, 2006; 26(2): 71-88. doi: 10.21608/besps.2006.37514

Erythrocytes’ Detoxifying and Anti-oxidant capabilities in Human Fascioliasis: Effect of Egaten

Bulletin of Egyptian Society for Physiological Sciences
Article 6, Volume 26, Issue 2, December 2006, Page 71-88  XML PDF (237.85 K)
Document Type: Original Article
DOI: 10.21608/besps.2006.37514
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Authors
Ebied SA* 1; Farag HF2; Youssef AI1; Ossman MM2; EL-Samak MY3; Hassnian NA1
1Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University
2Department of Parasitology, Medical Research Institute, Alexandria University
3Chemical Pathology, Medical Research Institute, Alexandria University
Abstract
The present study was carried out on 21 fasciolia patients (6 with acute fascioliasis
and 15 with chronic fascioliasis), and 10 age matched controls. Specific activities of
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX),
glutathione reductase (GR), glutathione S-transferase (GST), glucose 6-phosphate
dehydrogenase (G6-PD) as well as glutathione content (GSH) were measured in red
blood cells as it offers a number of advantage for studying the effects of oxidants.
Egaten (the human form of the fasciolocidal drug Triclabendazole) was supplemented
to all patients in a dose of 10 mg/kg body weight for 2 successive days. Before
treatment specific activities of SOD, GPX, GR, G6-PD and GSH content were
significantly reduced in the erythrocytes of all patients. The only exception was CAT
enzyme that didn't show any significant difference from controls and GST that showed
significant elevation. Liver function tests were significantly elevated in plasma of
fasicola patients. After treatment the level of all studied parameters except CAT were
significantly elevated than that before treatment and became more or less round the
figures of controls. Liver function tests became normal again, and anemia was
recovered. Conclusively, Egaten has cured all cases of fascioliasis under study and it
has abolished the effect of the parasite's oxidants on the antioxidant capabilities of
erythrocytes.
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