Nursing Interventions and Biochemical Markers in Early Detection of Neonatal Sepsis | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 729-742 PDF (488.42 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.303722.9998 | ||||
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| Authors | ||||
| Nawaf Sharqi Khalaf Alanazi1; Bandar Sharqi Khalaf Alanazi1; Khalid Sharqi Khalaf Alanazi1; Ahmed Ibrahim Mohammed Habadi2; Amnah Aziz Alsubaie3; Noora Mohammed Alnaji4; Fahad Abdu Shoei Humedi5; Ghadah Saud Alanazi6; Ashwaq Faleh Mater Anzy6; Atif Ogiby Alkhayri6; Fatimah Ali Hakami6; Fahd Nasser Alshakarah7; Saleh Mohammed Alklywy8; Salhah Ali Ibrahim Saddeg9; Shrouq Kassim Ahmed Moharram10 | ||||
| 1Nursing, Northern Area Armed Forces Hospital. King Khalid Military City, PO Box 10018, Hafr Al Batin 31991 , Kingdom of Saudi Arabia. | ||||
| 2Nursing technician, Prince Mohammad bin Nasser Hospital in Jazan, Kingdom of Saudi Arabia. | ||||
| 3Specialist Nursing, Imam Abdul Rahman Al-Faisal Hospital, Riyadh First Health Cluster, Kingdom of Saudi Arabia | ||||
| 4Specialist Nursing, Baish General Hospital, Jazan 87597, Kingdom of Saudi Arabia | ||||
| 5Nursing technician, Eradah for mental health Hospital in Jazan, Jazan Cluster, Kingdom of Saudi Arabia. | ||||
| 6Ministry of health, Kingdom of Saudi Arabia 7Epidemiological observer, Compliance Department, Riyadh Health, Kingdom of Saudi Arabia. | ||||
| 7Epidemiological observer, Compliance Department, Riyadh Health, Kingdom of Saudi Arabia. | ||||
| 8Ministry of health, Kingdom of Saudi Arabia | ||||
| 9Nursing technician, Primary Health Care Center in Albaidh, Riyadh, Kingdom of Saudi Arabia | ||||
| 10Nursing technician, Riyad, Kingdom of Saudi Arabia | ||||
| Abstract | ||||
| Aim: This study aims to explore the role of nurses and the use of biochemical markers in the management of neonatal sepsis. Methods: A comprehensive literature review was conducted to analyze current research on the roles of nurses in neonatal sepsis management and the utility of biochemical markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-8, IL-10), and soluble CD14 subtype presepsin (sCD14-ST) in diagnosing and monitoring neonatal sepsis. Studies focusing on clinical trials, observational studies, and meta-analyses published between 2000 and 2024 were included. Results: Nurses play a critical role in the early recognition and management of neonatal sepsis through vigilant monitoring, timely intervention, and effective communication with healthcare teams. Biochemical markers, particularly CRP and PCT, have shown promise in aiding early diagnosis and monitoring treatment response. IL-6, IL-8, IL-10, and sCD14-ST have also demonstrated potential as adjunctive markers in differentiating sepsis from non-infectious conditions. Conclusion: The integration of nurses in the multidisciplinary care team is crucial for improving outcomes in neonatal sepsis. Biochemical markers provide valuable adjuncts to clinical assessment, facilitating early diagnosis, appropriate antibiotic use, and monitoring of treatment efficacy. Further research is needed to standardize protocols for marker use, optimize diagnostic accuracy, and enhance the overall management of neonatal sepsis. | ||||
| Keywords | ||||
| Neonatal sepsis; nurses' role; biochemical markers; C-reactive protein; procalcitonin; interleukins; soluble CD14 subtype presepsin | ||||
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