The prognostic value of P53 and CA15.3 tumor markers in breast cancer patient | ||||
| Journal of Basic and Environmental Sciences | ||||
| Volume 11, Issue 3, July 2024, Page 240-249 PDF (1.22 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbes.2024.375506 | ||||
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| Authors | ||||
| Noha B.E Tohamy1; Nassr Allah Abd El-Hameid2; Reem El Shenawy3; Loay Kassem4; Mohamed N. Seddek5 | ||||
| 1Radioisotopes Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Egypt. | ||||
| 2Department Zoology Faculty of Sciences, Benha University, Egyp | ||||
| 3Departments of Biotechnology Research Institute, Microbial Biotechnology Division, National Research Centre, 12622, Cairo, Egypt | ||||
| 4Clinical Oncology Department, Kasr Alainy School of Medicine, Cairo University Cairo, Egypt. Medical Oncology Unit, Cairo Oncology Center, Cairo, Egypt | ||||
| 5Department Zoology Faculty of Sciences, Benha University, Egypt | ||||
| Abstract | ||||
| Breast cancer is the second most prevalent malignancy among women. The cancer antigen CA 15-3 has been used as a putative serum marker of occult and recurring breast carcinoma .The p53 gene is mutated in human cancer. Immunohistochemistry reveals that the mutant p53 protein is more stable and has a longer half-life compared to the wild type. This study aims to estimate the role of the p53 protein in diagnosing and confirming breast cancer compared to cancer antigen 15-3 (CA15-3.The current research involved 68 women diagnosed with breast cancer who were aged 30-60 years old. The control group consisted of 10 healthy women. Before surgery, sera samples were collected. The Sandwich-ELISA technique measures the amount of p53 protein in sera. An immunoradiometric assay (IRMA) kit was used to measure the sera CA 15-3 levels. The study found a higher level of CA15-3 In breast cancer patients (186.7±218) compared to healthy control groups (8.88±3.7). There are no significant associations between p53 protein levels and patient clinical features such as age and grade. Furthermore, the p53 protein value did not correlate with serum CA 15-3. | ||||
| Keywords | ||||
| Breast cancer; Tumor marker; CA15-3; p53 protein | ||||
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