PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 44, Issue 2, April 1996, Page 453-461 PDF (4.37 MB) | ||||
| DOI: 10.21608/vmjg.1996.376557 | ||||
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| Authors | ||||
| A ABD EL-ATY1; A GOUDAH1; ATEF M.* 2; AMER M.2; El- BANNA A.2; SOLIMAN A.2 | ||||
| 1Department of Pharmacology, FACULTY OF Veterinary medicine ,Cairo University | ||||
| 2Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University | ||||
| Abstract | ||||
| The pharmacokinetic profile, tissue distribution and residual content of pipemidic acid were studied in normal and nephritic rats. The maximum serum concentration was reached after 1 hr. in both normal and nephritic rats following oral administration of 50 mg/kg b. wt. Lower serum concentrations were detected in nephritic rats at corresponding time intervals as compared with healthy ones. Following. The intravenous injection of pipemidic acid, the resulting curves were best fitted to follow two compartment open model. The drug was highly. distributed in all tested tissues and completely disappeared from all tissues after 9 and 15 days in healthy and nephritic rats following its oral administration in a dose of 50 mg/kg b. wt. twice daily for 5 successive days. | ||||
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