DISPOSITION KINETICS OF APRAMYCIN IN GOATS | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 44, Issue 2, April 1996, Page 471-477 PDF (4.01 MB) | ||||
| DOI: 10.21608/vmjg.1996.376575 | ||||
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| Authors | ||||
| EL-GENDI Y.* ; HASHEM M.; AMER M. | ||||
| Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University. | ||||
| Abstract | ||||
| The disposition kinetics and milk and urine concentration of apramycin were estimated in six goats. Following intramuscular and intravenous injection of 20 mg/kg b.wt., blood milk and urine samples were collected at 5, 15, 30 min., 1, 2, 4,6, 8,10,12 hours post injection. The collected samples were used for determination of apramycin concentration using the microbiological assay method. Following intramuscular injection of apramycin, the highest concentration in serum was recorded at 1 hour with t0.5(ab) value f 47.78 min. and t0.5 (β) £ 1.53 h. The peak milk and urine concentration was reached at 4 hours. Following intravenous injection of apramycin it follows two-compartment model with to t 95(a) 14.11 min. and tg 5 (β)) 3.22 h., Vc 0.97 L/kg. The Cl(B)) was 1.668 ml/kg. The mean systemic bioavailability was 78.25%. The protein binding percent of apramycin of serum and milk was 8.5% and 39.25% respectively. | ||||
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