Evaluation of Pattern and Outcome of Cancer Patients with Febrile Neutropenia Presented in Clinical Oncology Department Assiut University from 2018-2022, A Real Life Study. | ||||
SECI Oncology Journal | ||||
Volume 12, Issue 3, July 2024, Page 270-279 | ||||
View on SCiNiTO | ||||
Abstract | ||||
Background and aims: Febrile neutropenia (FN) is the most serious complication of chemotherapy which requires adequate assessment and treatment. The objective of this study was to evaluate the epidemiological pattern and clinical outcomes of chemotherapy-induced FN. Methods: This was a single center retrospective observational study conducted at the Clinical Oncology Department of Assiut University Hospital Medical records of patients with cancer and FN were reviewed from January 2018 to December 2022. Results: The incidence of FN was 3.8%. A total of 152 patients were included with a mean age of 51 years and 71% were females. Most patients (92%) had solid malignancies. It occurs most frequently (86.8%) during the first 3 cycles of chemotherapy. Twenty-two patients (14.5%) had a high risk Multinational Association for Supportive Care in Cancer (MASCC) score, and 23 patients (15%) received primary prophylaxis. Twenty patients (13.2%) and 60 patients (39.5%) required chemotherapy dose reduction and cycle delay respectively. Twenty-two patients (14.5%) needed hospitalization and 8 patients (5.3%) died during their admission. Baseline MASCC score (<21), long duration of FN (>4 days), chemotherapy delay and respiratory tract infection were factors significantly associated with mortality. Conclusions: This study showed that the incidence of FN was common among solid cancer. It occurs most frequently during the first three cycles of chemotherapy. Physicians should be aware of factors associated with mortality to provide a better monitor, management and improve the outcome of FN. | ||||
Keywords | ||||
febrile neutropenia; cancer; chemotherapy; clinical outcomes | ||||
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