Anticancer; Antiviral activities and Phytochemical studies on Cleome droserifolia (Forssk.) Delile in Nabq Protectorate, South Sinai, Egypt | ||||
| Egyptian Journal of Botany | ||||
| Article 34, Volume 64, Issue 3, September 2024, Page 369-380 PDF (1.74 MB) | ||||
| Document Type: Regular issue (Original Article) | ||||
| DOI: 10.21608/ejbo.2024.292645.2863 | ||||
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| Authors | ||||
Walaa Abdo El-Alem  1; Zeinab Ahmed Said El-Swaify1; Ahmed Abdallah Mohamed2; Ramadan Ibrahim Bedair3; Om Mohamed Ahmed Khafagi4
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| 1Botany and Microbiology Department, Faculty of Science, Al-Azhar University (Girls Branch), Nasr City, Cairo, Egypt | ||||
| 2Environmental Researcher-Egyptian Environmental Affairs Agency | ||||
| 3Department of Botany and Microbiology, Faculty of Science, Al-Azhar University (Boys branch), Cairo, Egypt | ||||
| 4Botany and Microbiology Dept. al azhar University(girls branch) | ||||
| Abstract | ||||
| The Genus Cleome has many beneficial properties and phytochemical components, and considerable potential as a novel therapeutic source. This study assessed the phytochemical composition, antiviral activity against HAV, anticancer effects against HepG2 (hepatocellular carcinoma cell line) and MCF7 (human cancer breast cell line), and antimicrobial efficacy of an ethanol 70% aerial parts extract from Cleome droserifolia in vitro. In 70% ethanol extract of Cleome droserifolia, flavonoids, tannins, alkaloids, saponins, terpenes, and sterols were identified. The Cleome droserifolia extract showed great efficacy against HAV, the HepG2 and MCF7 cell lines, with a selective index of 3.85, 2.253 and 1.18 respectively. It is also effective against Gram-positive Bacillus cereus and Gram-negative Enterobacter cloacae bacteria and Fungus; Candida albicans. Benzene-1-pentyloctyl (5.77%), Benzene-1-butylheptyl (5.06%), Benzene-1-methyldecyl (4.93%), Benzene-1-methyldecyl (4.77%), Benzene-1-methylundecyl (4.66%) and Benzene-1-pentylheptyl (4.38%) were found to be the most abundant components from Cleome droserifolia petroleum ether extract by using a Gas Chromatography–Mass Spectrum (GC-MS) analysis. Conversely, the results for indolizine, retinal, and retinol were 0.44%, 0.54%, and 0.06%, respectively. | ||||
| Keywords | ||||
| phytochemical constituents; Anticancer; Antimicrobial; Antiviral; Cleome droserifolia | ||||
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