Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians | ||||
Egyptian Journal of Cancer and Biomedical Research | ||||
Article 4, Volume 3, Issue 1 - Serial Number 4, April 2019, Page 21-30 PDF (1.03 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jcbr.2019.37766 | ||||
View on SCiNiTO | ||||
Authors | ||||
Yousry E El-Bolkiny 1; Fuad K Harras2; Merveet A Mansour3; Abdelhalim A Alkhazendar3; Mohamed Raghaey4 | ||||
1Department of Zoology, Faculty of Science, Tanta University, Egypt | ||||
2Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
3Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt | ||||
4Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
Abstract | ||||
The present work was planned to find a correlation between HCV infection and diabetes mellitus (DM) incidence in Egyptian patients by finding a possible relationship between HCV antibodies and both anti-insulin antibodies (AIAs) and pancreatic islet cell antibodies (PICAs). The screening results showed that the percentage of HCV patients out of 200 subjects were 35.5 and 14.5% in males and females, respectively. Also, the association between DM and HCV were 13.21 and 13.64% in men and women, respectively. The titers of antibodies in diabetic or non-diabetic patients ranged from 30 - 58 for AIAs and from 30 - 40 for PICAs, The percentage of patients with raised serum transaminases was significantly more in DM patients with positive HCV antibody (52.3%) than DM patients with negative HCV antibody (16.7%). Conclusion, it can be concluded that diabetic or non-diabetic patients with HCV might have a rise titer of the antibodies toward insulin or its secretory cells in pancreas or toward both. where are more susceptible to both HCV-infection and antibodies than women, indicating to here is a significant association between HCV infection and induction of diabetes in Egyptians. | ||||
Keywords | ||||
HCV; Anti-insulin antibodies; Diabetes mellitus | ||||
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