Chemokines profile as early predictor for complicated pregnancy among primigravida at high-risk of toxoplasmosis | ||||
Parasitologists United Journal | ||||
Article 6, Volume 17, Issue 2, August 2024, Page 112-120 PDF (654.15 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/puj.2024.287295.1246 | ||||
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Authors | ||||
Heba Aboelela 1; Marwa Naguib1; Waleed Tawfik2; Ghada Mahmoud3; Dina Mohammed1 | ||||
1Departments of Medical Parasitology, Faculty of Medicine, Benha University, Benha, Egypt | ||||
2Departments of Obstetrics & Gynecology , Clinical , Faculty of Medicine, Benha University, Benha, Egypt | ||||
3Departments of Pathology , Faculty of Medicine, Benha University, Benha, Egypt | ||||
Abstract | ||||
Background: Serum chemokines have variable functions related to angiogenesis that might be implicated in adverse pregnancy outcomes. Their assessment in toxoplasmosis during antenatal care will reduce fetal and neonatal morbidity. Objective: To evaluate the distinguishing ability of chemokines in predicting the outcome of toxoplasmosis and its-related pregnancy complications in vulnerable primigravida. Patients and Methods: The study included three groups of pregnant women; 60 high risk primigravida (A), 60 low risk primigravida (B) for criteria for toxoplasmosis, and 60 multigravida (C) who had a history of toxoplasmosis-related pregnancy complications. Blood samples were obtained to assess seropositivity for anti-T. gondii Igs, M and G and for ELISA estimation of interleukin-6 (IL-6), C-X-C chemokine-ligand-9 (CXCL9), chemotactic-competent motif ligand-2, and -5 (CCL2 and CCL5). Ability of the estimated parameters to predict the reported pregnancy complications was evaluated. Results: In group A, the number of positive samples was higher and showed significantly higher CXCL9 levels than group B samples. In seropositive patients, CCL2 and 5 levels were significantly higher in group < br />A, while in group B samples, only serum CCL2 levels were significantly higher. In addition, CCL2 levels were higher in IgG or IgG/IgM of group B than in group A subjects. Serum IL-6 levels were significantly higher in seropositive than seronegative women and in IgM than in IgG or IgG/IgM samples of both A and B groups. In group C with pregnancy complications, especially spontaneous abortion (SA), early pregnancy loss (EPL) and preterm labor were the most frequently encountered complications. Pregnancy complications were significantly frequent among group A women. While high CXCL9 levels alone could predict pregnancy complications, high IL-6 levels could predict seropositivity, and seropositivity might predict SA or EPL. Conclusion: Serum CXCL9 and CCL2 levels could distinguish women vulnerable to developing pregnancy complications. High CXCL9 levels could predict SA or EPL, while coupled with high IL-6 levels it could distinguish seropositivity in primigravida. | ||||
Keywords | ||||
chemokines; early predictors; early pregnancy loss; high risk; spontaneous abortion; toxoplasmosis | ||||
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