Evaluation of in vitro growth inhibitory effects of ebselen on Babesia and Theileria parasites | ||||
| Journal of Current Veterinary Research | ||||
| Article 5, Volume 10, Issue 1, 2016, Page 34-38 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcvr.2016.37880 | ||||
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| Authors | ||||
Mahmoud AbouLaila  1; Naoaki Yokoyama2; Ikuo Igarashi2
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| 1Department of Parasitology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32511, Minoufiya, Egypt | ||||
| 2National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan | ||||
| Abstract | ||||
| Ebselen, a seleno-organic compound, has antioxidant, anti-inflammatory, and antiparasitic effects. In this study, the inhibitory effects of ebselen were evaluated against three Babesia species and Theileria equi in vitro cultures. The drug showed significant growth inhibition in serum-free GIT medium from an initial parasitemia of 1% for Babesia bovis and Babesia caballi with IC50 values of 12.73 and 19.55 μM, respectively. Complete inhibition was observed at 100 and 50 μM of ebselen for the Babesia bovis and Babesia caballi, respectively. Ebselen-treated parasites were swollen compared with parasites in the control culture. On the other hand, there was no growth inhibitory effects for any of the used concentrations of ebselen on the parasites in cultures used media supplemented with either bovine or equine sera. The present study shown that serum factors may inactivate ebselen; therefore, it could not be used for treatment of Babesia and Theileria parasites. | ||||
| Keywords | ||||
| Ebselen; Babesia; Theileria equi; in Vitro | ||||
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