Tim-4 an emerging immune modulatory molecule | ||||
Journal of Current Veterinary Research | ||||
Article 9, Volume 10, Issue 1, 2016, Page 64-71 | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jcvr.2016.37887 | ||||
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Author | ||||
Alaa E.H. Mostafa | ||||
Dean of faculty of veterinary medicine, Sadat university | ||||
Abstract | ||||
Tim-4 is a member of the T-cell immunoglobulin mucin (Tim) family of proteins that has been implicated in the control of T cell-mediated immune responses. Tim-4 that is expressed on various macrophages subsets has been recognized as a phosphatidylserine receptor mediating phagocytosis of apoptic cells by peritoneal macrophages. The functions of Tim-4 in immune responses, however, are still unclear. In this study, results showed that blocking of Tim-4 that is preferentially expressed on F4/80+ peritoneal macrophages results in increased C04+ T cells proliferation. Additionally the administration of anti-Tim4 monoclonal antibody decreased the percentage of Foxp3+CD4+CD25+ T-regulatory cells in lymph nodes of immunized mice suggesting an emerging role of Tim-4 molecule in immune regulation as a promising target for treatment and prevention of autoimmune diseases. | ||||
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