Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation
Abou Baker, D., Elshimy, A., Hassan, E., El Gengaihi, S. (2024). Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation. EKB Journal Management System, 67(11), 9-15. doi: 10.21608/ejchem.2024.306104.10056
Doha H Abou Baker; Abdelsamed I. Elshimy; Emad Hassan; Souad El Gengaihi. "Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation". EKB Journal Management System, 67, 11, 2024, 9-15. doi: 10.21608/ejchem.2024.306104.10056
Abou Baker, D., Elshimy, A., Hassan, E., El Gengaihi, S. (2024). 'Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation', EKB Journal Management System, 67(11), pp. 9-15. doi: 10.21608/ejchem.2024.306104.10056
Abou Baker, D., Elshimy, A., Hassan, E., El Gengaihi, S. Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation. EKB Journal Management System, 2024; 67(11): 9-15. doi: 10.21608/ejchem.2024.306104.10056

Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation

Egyptian Journal of Chemistry
Volume 67, Issue 11, November 2024, Page 9-15  XML PDF (189.77 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.306104.10056
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Authors
Doha H Abou Baker email orcid 1; Abdelsamed I. Elshimy2; Emad Hassanorcid 3; Souad El Gengaihi2
1Pharmaceutical and drug discovery institute, National Research Centre
2pharmaceutical and drug discovery institute, National Research Centre
3Medicinal and Aromatic Plants Dept., Pharmaceutical and Drug Industries Division, National Research Centre, Cairo, Egypt.
Abstract
Cancer, one of the leading causes of death, has seen progress in the development of drugs for intervention. However, these drugs often come with severe side effects. As a result, there has been a growing interest in functional food and natural products for their potential as anti-cancer therapies. One such example is orange peels (OPs) and their derived extracts, which demonstrate strong anti-cancer properties due to their high flavonoid content. OPs contain numerous bioactive compounds that can be used in drug development. This study aimed to isolate flavonoids from OPs and assess their anti-cancer potential against Hep-G2 cancer cells. High-performance liquid chromatography (HPLC) analysis revealed 19 flavonoid compounds in OPs, with chrysin, kaempferol, and catechin being the major constituents. The alcoholic extract of OPs exhibited antioxidant potential against ABTS and DPPH. Six flavonoids were isolated from citrus peel. These are: Kaempferol-3-O-rutinoside(nicotiflorin), Isorhamnetin-3-O-B-rutinoside, Rutin, Qercetin-3-O-β-glucoside, Isorhamnetin and hesperdin. The isolated compounds exhibited higher levels of cytotoxicity to cancer cells. These findings support the use of OPs as potential anticancer agents.
Keywords
Fruit by products; Citrus peels; Flavonoids; Liver cancer
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