Evaluation of Antioxidant and anti-Inflammatory Activities of 4-((quinolin-2-yl) methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one on Ehrlich Ascites Carcinoma Bearing Mice | ||||
| Scientific Journal for Damietta Faculty of Science | ||||
| Volume 14, Issue 2, 2024, Page 1-12 PDF (1.06 MB) | ||||
| Document Type: Original articles | ||||
| DOI: 10.21608/sjdfs.2024.312894.1176 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rasha Fekry Zahran   1; Ghada Mohamed Rady2; Adel Zaki El-Sonbati 3
| ||||
| 1Chemistry Department (Biochemistry Division), Faculty of Science, Damietta University, Egypt. | ||||
| 2Department of Chemistry (Biochemistry Division), Faculty of Science, Damietta University, Egypt. | ||||
| 3Chemistry Department, Faculty of Science, Damietta University, Egypt. | ||||
| Abstract | ||||
| There is a persistent need for new chemotherapeutic drugs, indicating a vital requirement for innovative techniques. The purpose of this study was to assess the protective capabilities of 4-((quinolin-2-yl) methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (QMP) against the alterations in oxidative stress, hematological, and TNF-α generated by Ehrlich ascites carcinoma (EAC) cells in mice. The study involved the division of 100 adult male Swiss albino mice into 5 groups, with each group consisting of an equal number of mice. The groups were labeled as follows: G1 (negative control), G2 (1% DMSO), G3 (QMP), G4 (EAC), and G5 (EAC +QMP). The anticancer efficacy of (QMP) was determined by assessing antioxidant, hematological parameters, and the level of TNF-α. EAC group had significant elevations in hematological parameters, NO, MDA, and TNF-α levels. In contrast, the (EAC+ QMP) group had decreased levels of hematological parameters, NO, MDA, and TNF-α. The findings of our study suggest that (QMP) possesses anti-inflammatory and antioxidant capabilities, which have the ability to reduce oxidative stress in EAC cells by enhancing the system of antioxidant defense. | ||||
| Keywords | ||||
| QMP; EAC cells; anticancer; anti-inflammatory; antioxidants | ||||
|
Statistics Article View: 22 PDF Download: 25 |
||||
