Phytoestrogens Soymilk and Fenugreek Oil Perturb Lipid and Hormonal Profile and Other Physiological Parameters of Male Albino Rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 16, Volume 76, Issue 2, July 2019, Page 3494-3499 PDF (450.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2019.37937 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman G.E. Helal   1; Hewaida, A.E. Fadal2; Gavin C. Ikechukwu3; Mohamed A. Abd-El-Aziz4; Shaimaa S. Ahmed1
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| 1Zoology Department, Faculty of Science, Al-Azhar University (Girls) | ||||
| 2Physiology and Nutritional Chemistry, National Nutrition Institute, Cairo, Egypt | ||||
| 3Biochemistry Department, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Nigeria | ||||
| 4Physiology Department, Faculty of Medicine, Al-Azhar University (Boys), Cairo, Egypt | ||||
| Abstract | ||||
| Background: phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens. They have been investigated at the epidemiological, clinical and molecular levels to determine their potential health benefits. Aim: the present study was carried out to investigate some biochemical effects of fenugreek oil and soymilk on male albino rats. Materials and Methods: eighteen (18) animals were divided randomly into three groups with 6 animals per group. Group “1” received normal saline 1 mL/kg body weight orally for four weeks. Group “2” rats were treated with oral dose of soymilk 1 ml/kg body weight/day once daily for four weeks, while rats in group “3” were treated with oral dose of fenugreek 1 ml/kg body weight/day once daily for four weeks. Blood samples were collected on the last day of the experiment for biochemical analysis. Results: the fenugreek oil and soymilk induced highly significant decrease (p<0.01) in total cholesterol, triacylglycerol, low-density lipoprotein, very low-density lipoprotein, low-density lipoprotein high-density lipoprotein ratio (LDL/HDL) and a significant increase (p<0.05) in high-density lipoprotein. The results also showed highly significant decrease in follicle stimulating hormone, luteinizing hormone, testosterone and sperm count compared to normal control group. Conclusion: the results of this study suggest that high levels of fenugreek and soymilk intake can cause hormonal disturbance and decrease sperm count. | ||||
| Keywords | ||||
| Fenugreek oil; Soymilk; Lipid profile; Phytoestrogen; hormonal profile | ||||
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