Association study of rs2243188 (interleukin-19) and rs933717 (MAP1LC3B) polymorphisms with Juvenile systemic lupus erythematosus and Juvenile lupus nephritis in Egyptian population | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 25, Volume 33, Issue 4, October 2024, Page 203-209 PDF (345.69 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2024.316603.1320 | ||||
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| Authors | ||||
Ingy Ashmawy   1; Abeer Ramadan2; Nora Y. Elsaid 3; Maha Abdelhadi4; Irene Bishai5
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| 1Department of Clinical and Chemical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt | ||||
| 2Department of Molecular Genetics and Enzymology, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt | ||||
| 3Rheumatology Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| 4Internal Medicine Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt | ||||
| 5Clinical and Chemical Pathology Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: An autoimmune connective tissue illness that affects several organs and lowers a patient's quality of life is the juvenile systemic lupus erythematosus (JSLE) and associated juvenile lupus nephritis (JLN). Interleukin-19 (IL-19) has both anti- and pro- inflammatory actions. LC3-associated phagocytosis (LAP) regulates immune responses to dying cells. Polymorphisms disrupting both mechanisms have been correlated to autoimmune diseases. Objective: to determine whether single-nucleotide polymorphisms (SNPs) of rs2243188 (IL-19) and/or rs933717 (MAP1LC3B) exhibit meaningful relationship with JSLE and /or JLN in the Egyptian population. Methodology: forty-seven JSLE patients and fifty matched healthy controls (HC) were included. SNPs identification was done using allelic discrimination real-time polymerase chain reaction (PCR) technology. Results: Genotyping of rs933717 and rs2243188 showed no statistical difference between the two studied groups with (P=0.206 and 0.468 respectively). Similarly, there was no significant difference in allele frequencies in neither rs933717 nor rs2243188 (P= 0.362 and 0.552 respectively). Twenty-nine out of the 47 JSLE patients (61.7%) displayed JLN symptoms. Similarly, JLN revealed no significant difference in either the genotype distribution or the allele frequency in the dominant/negative model for both genes. Likewise, there was no significant difference in the frequency of any allele concerning rs933717 or rs2243188, (P= 0.309 and 0.196 respectively). Conclusion: Interleukin-19 rs2243188 and MAP1LC3B rs933717 polymorphisms do not seem to play any role in the pathogenesis of JSLE or JLN in Egyptian population. | ||||
| Keywords | ||||
| IL-19 rs2243188; MAP1LC3B rs933717; Juvenile systemic lupus: SLE; Lupus nephritis | ||||
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