Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit
Zakria, R., Assar, E., Ismael, Y., Mohamed, S., Badr, N. (2025). Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit. EKB Journal Management System, 42(1), 164-176. doi: 10.21608/bmfj.2024.308995.2155
Rasha Mohamed Zakria; Effat Hussein Assar; yasser Mohamed Ismael; Samira Shehata Mohamed; Nouran Ramzy Badr. "Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit". EKB Journal Management System, 42, 1, 2025, 164-176. doi: 10.21608/bmfj.2024.308995.2155
Zakria, R., Assar, E., Ismael, Y., Mohamed, S., Badr, N. (2025). 'Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit', EKB Journal Management System, 42(1), pp. 164-176. doi: 10.21608/bmfj.2024.308995.2155
Zakria, R., Assar, E., Ismael, Y., Mohamed, S., Badr, N. Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit. EKB Journal Management System, 2025; 42(1): 164-176. doi: 10.21608/bmfj.2024.308995.2155

Prognostic Value of Neutrophil to Lymphocyte Ratio Marker in Chest Infection in Pediatric Intensive Care Unit

Benha Medical Journal
Article 17, Volume 42, Issue 1, January 2025, Page 164-176  XML PDF (993.81 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.308995.2155
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Authors
Rasha Mohamed Zakria1; Effat Hussein Assar2; yasser Mohamed Ismael3; Samira Shehata Mohamed email 4; Nouran Ramzy Badr1
1Lecturer of Pediatrics Faculty of Medicine - Benha University
2Professor of Pediatrics Faculty of Medicine - Benha University
3Professor of clinical pathology Faculty of Medicine - Benha University
4M.B.B.Ch. Benha University
Abstract
Background: Acute respiratory failure in children, often due to pneumonia and bronchiolitis, commonly leads to acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) in Pediatric Intensive Care Units (PICUs). The neutrophil-to-lymphocyte ratio (NLR) is a potential prognostic marker for these conditions. This study aimed to evaluate NLR as a predictor of disease severity and outcomes, including mechanical ventilation and mortality, in pediatric chest infections in the PICU. Methods: This cross-sectional study included 100 children admitted to the PICU at Benha University Hospital for chest infections. Clinical data, lab results, and outcomes were assessed for each patient. Results: Of the 100 children (56 males, 44 females), pneumonia was diagnosed in 70%. NLR was significantly higher in patients needing mechanical ventilation (p < 0.001) and those who died (p < 0.001). NLR correlated positively with CRP, CO2, and hospital stay duration, and negatively with platelets, pH, and HCO3. ROC analysis showed an AUC of 0.876 for predicting mechanical ventilation and 0.950 for predicting mortality, with high sensitivity and specificity at cutoffs of >5.1 and >5.9, respectively. Conclusion: NLR is a valuable, rapid, and cost-effective prognostic marker for predicting the need for mechanical ventilation and mortality in children with chest infections in the PICU.
Keywords
NLR; Chest Infection; PICU
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