Effect of Experimental Clostridium perfringens Infection on Some Immunological, Hematological and Biochemical Values in Broiler Chickens | ||||
| Zagazig Veterinary Journal | ||||
| Article 10, Volume 47, Issue 2, June 2019, Page 222-233 PDF (210.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zvjz.2019.12216.1036 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Marwa Khodary  1; Nasr Nasr el-Deen2; Ibtisam Gamal el-Deen1
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| 1Department of Clinical Pathology, Animal Health Research Institute, Zagazig, 44516, Egypt | ||||
| 2Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511 | ||||
| Abstract | ||||
| This study aimed to demonstrate the effect of Cl. perfringens infection on broiler chickens and compares between the effect of amoxicillin and / or organic acids on Cl. perfringens infection through the evaluation of hemogram, blood chemistry, hepato-renal functions and immune response through ELISA technique. One hundred one-day old chicks were divided into five equal groups. Group (1): negative control, Group (2): Clostridium perfringens type A (1.9×109 organism/ml) infected broilers, Group (3): infected chickens treated with amoxicillin (15 mg/kg. wt.) for 5 successive days, Group (4): chickens administered organic acids (1 mL /L water) then infected and Group (5): chickens infected and treated with both amoxicillin and organic acids. Cl. perfringens infection resulted in decreased appetite, ruffled feathers and brownish diarrhea with sudden death in some cases with a mortality rate up to 25%. Birds infected and treated with amoxicillin showed mild clinical signs with 15% mortalities. Majority of chickens supplemented with organic acids followed by Cl. perfringens infection or with organic acids and amoxicillin showed depression with a mild diarrhea and 10% mortality rate. Chickens infected with Cl. perfringens had macrocytic hypochrmic anemia, leukocytosis, heterophilia and monocytosis. In addition to, a significant decrease of total protein, albumin, phagocytic % and phagocytic index with a significant increase of total golbulins, liver enzymes activities, serum uric acid, creatinine and glucose levels. Treatment of Cl. perfringens infection with amoxicillin, organic acids alone or in combination resulted in a positive effect in treatment, ameliorating the severity of infection and a significant improvement in some immunological and biochemical parameters, the best results were observed with combination. | ||||
| Keywords | ||||
| Clostridium perfringens; amoxicillin; organic acids; chickens; Phagocytic activity | ||||
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