Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines
Hassan, A., El-Hifnawi, H., Ahmed, W. (2019). Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines. EKB Journal Management System, 3(3), 117-133. doi: 10.21608/aprh.2019.10458.1081
Aisha Y. Hassan; Hala N. El-Hifnawi; Wafae M. Ahmed. "Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines". EKB Journal Management System, 3, 3, 2019, 117-133. doi: 10.21608/aprh.2019.10458.1081
Hassan, A., El-Hifnawi, H., Ahmed, W. (2019). 'Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines', EKB Journal Management System, 3(3), pp. 117-133. doi: 10.21608/aprh.2019.10458.1081
Hassan, A., El-Hifnawi, H., Ahmed, W. Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines. EKB Journal Management System, 2019; 3(3): 117-133. doi: 10.21608/aprh.2019.10458.1081

Design, Synthesis and in Vitro Evaluation of Antimicrobial and Anticancer Activity of Some Novel α,β-Unsaturated Ketones and their Corresponding Fused Pyridines

Journal of Advanced Pharmacy Research
Article 3, Volume 3, Issue 3, July 2019, Page 117-133  XML PDF (953.35 K)
Document Type: Research Article
DOI: 10.21608/aprh.2019.10458.1081
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Authors
Aisha Y. Hassan email 1; Hala N. El-Hifnawi2; Wafae M. Ahmed
1Chemistry Department, Faculty of Science, Girl's Branch, Al-Azhar University, Nasr City, Cairo, Egypt .
2Microbiology Department, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt.
Abstract
Objective: This study aimed  synthesis of fused pyridine due to the importance of these heterocycles as antimicrobial and anticancer. Method: Some novel substitutedpyrido[3,2-c]pyran-6-one,pyrido[2,3-c]isoxazole,pyrazolo[4,3-c] pyridine, pyrido[4,3-c]pyrimidine, pyrido[3,2-c]pyrimidine[2,3-b]triazine-2-thione and pyrido[3,2-c]pyrano[2,4-d] pyrimidine-2-thione derivatives have been reported to possess various pharmacological activities like antimicrobial and antitumor. Results: A novel series of azoles and azines were designed and prepared via reaction of 3-(arylidene)-1-methy-4-piperidonewith some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusion: It could be concluded that the tested compounds 14a,e, 13a, 11b and 17d1 have highest antibacterial activity. Compounds 11b, 13a, 14c,e,g, 16e, 17d1 have antifungal activity than antibiotic standard (Nystatin) used. Compound 13a and 25a have shown good anticancer agent.
ifungal activity than antibiotic standard (Nystatin) used. Compound 13a and 25a have shown good anticancer agent.
Keywords
Antibacterial; Antifungal; Anticancer; Pyrido[3,2-c] pyranone; Pyrazolo [3,4-c] pyridine; Pyrido[4,3-c] pyrimidine; Pyrido[3,2-c]pyrano[2,4-d] pyrimidine
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