Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders
Rashad, N., Seleem, D., Abdelsalam, H., Elnagar, W., Fathy, M., Ali, D., Soliman, S. (2024). Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders. EKB Journal Management System, 45(1), 13-20. doi: 10.21608/EJPSY.2024.380493
Nearmeen M. Rashad; Dina Ahmed Seleem; Heba A. Abdelsalam; Walid Mohamed Elnagar; Maha Abdelhamid Fathy; Dina Ahmed Seleem Ali; Sameh A. Soliman. "Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders". EKB Journal Management System, 45, 1, 2024, 13-20. doi: 10.21608/EJPSY.2024.380493
Rashad, N., Seleem, D., Abdelsalam, H., Elnagar, W., Fathy, M., Ali, D., Soliman, S. (2024). 'Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders', EKB Journal Management System, 45(1), pp. 13-20. doi: 10.21608/EJPSY.2024.380493
Rashad, N., Seleem, D., Abdelsalam, H., Elnagar, W., Fathy, M., Ali, D., Soliman, S. Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders. EKB Journal Management System, 2024; 45(1): 13-20. doi: 10.21608/EJPSY.2024.380493

Association of Spexin with Metabolic and Reproductive Features of Polycystic Ovary Syndrome in Women with Eating Disorders

Egyptian Journal of Psychiatry
Volume 45, Issue 1, January 2024, Page 13-20  XML PDF (566 K)
DOI: 10.21608/EJPSY.2024.380493
View on SCiNiTO View on SCiNiTO
Authors
Nearmeen M. Rashad1; Dina Ahmed Seleem2; Heba A. Abdelsalam2; Walid Mohamed Elnagar3; Maha Abdelhamid Fathy4; Dina Ahmed Seleem Ali email 5; Sameh A. Soliman6
1aInternal Medicine Department, Faculty of Medicine, Zagazig University, Egypt.
2Psychiatry Department; Faculty of Medicine, Zagazig University, Egypt.
3Obstetrics and Gynecology; Faculty of Medicine, Zagazig University, Egypt.
4Physiology Department, Faculty of Medicine, Zagazig University
5Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt
6Internal Medicine Department; Faculty of Medicine, Zagazig University; Egypt.
Abstract
Background
Polycystic ovary syndrome (PCOS) is connected with metabolic, reproductive, and psychiatric disorders such as depression, anxiety and eating disorders (ED). Gonadotropin-releasing hormone secretion is regulated by neurohormones, such as spexin (SPX). This study aimed at assessing the serum level of SPX in women with PCOS and to evaluate its association with eating disorders, metabolic and reproductive features.
Subjects and Methods
A case control study was conducted on 80 women; 40 women with PCOS and 40 healthy women as a control group. Serum SPX was assessed by an enzyme-linked immune absorbent assay. Depression, anxiety and ED were assessed using the Structured Clinical Interview for DSM-IV-TR axis I disorders, Hospital Anxiety and Depression scale and Eating Disorder Examination Questionnaire.
Results
Serum SPX values were lower in the PCOS group (0.62±0.312) compared to the control group (1.16±0.49, P ˂0.001). The prevalence of ED among PCOS group was 32.5% (n= 13) vs 15% in the control group (n= 6) with binge eating disorder (BED) having the highest prevalence of ED among patients with PCOS. PCOS women with ED had lower values of SPX compared to PCOS women without ED (0.532±0.275 vs. 0.747±0.33, respectively, P ˂0.001). There were significant negative correlations between serum SPX and phenotypic features of the PCOS group, as well as ED parameters. BMI, depression, and anxiety scores were independently correlated with SPX level in the PCOS group.
Conclusions
PCOS is associated with metabolic and eating disorders in particular BED. SPX levels were significantly lower in PCOS women and ED and inversely associated with metabolic, reproductive, and eating disorders.
Keywords
BED; Eating disorders; Metabolic; PCOS; Reproduction; Spexin
Statistics
Article View: 180
PDF Download: 122