Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens | ||||
Novel Research in Microbiology Journal | ||||
Volume 8, Issue 5, September and October 2024, Page 2604-2631 PDF (757.29 K) | ||||
Document Type: Review Article | ||||
DOI: 10.21608/nrmj.2024.306911.1663 | ||||
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Authors | ||||
Subhasmita Mallik 1; Samikshya Nayak 1; Arpita Panda 2; Smrutirekha Behera 1; Kamalakanta Swain 2; Archita Patra 1; Rukmini Mishra 1; Jatindra Nath Mohanty 1 | ||||
1Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India | ||||
2Department of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, India | ||||
Abstract | ||||
In recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing on plant-based products due to their antibiotic properties and lack of associated antibiotic resistance. Plant-based nanoparticles present several benefits, including their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this review were exploration of the complexities and limitations of plant-based phytochemical extraction processes and addressing the challenges of synthesizing nanoparticles for combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phyto-based nanoparticles in drug delivery systems to treat MDR infections; both alone and in combination with antibiotics, and provided a critical assessment of their potentials as a research avenue. For this, we have taken the diverse methodologies that were previously used to select the best possible process to tackle MDR pathogens using plant extracts. Although using plant-derived products and nanoparticles is a novel approach to address the antimicrobial drug resistance; however, detailed researches are necessary to explore their antibacterial attributes. Specifically, transcriptome profiling should be employed to identify therapeutic molecules from plant-based products that can effectively combat MDR bacteria before synthesis of nano-drugs. The outcomes of this study will enable the researchers to obtain the best approaches to tackle MDR pathogens through using the nano-based phytochemicals. | ||||
Keywords | ||||
Phyto-based nanoparticles; MDR pathogens; Tackling strategies; Nano drugs | ||||
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