In vitro assessment of some deodorant ingredients and determination of malodor inhibiting potentials of ascorbic acid, orlistat and mastic gum | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 4, Volume 23, Issue 1, 2014, Page 44-57 PDF (390.25 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.2014.38180 | ||||
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Authors | ||||
Rasha Mosbah1; Fathy Serry2; Eman El Masry2 | ||||
1Zagazig University Hospitals | ||||
2Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
Abstract | ||||
Axillary microbial flora has a role in sweat odor formation by transformation of odorless natural secretions into volatile odorous molecules. From 190 axillary isolates obtained from healthy volunteers, 97 isolates, representing three genera; Stahylococcus (39), Micrococcus (13), Corynebacterium (45) were screened for their ability to produce malodorous metabolites from testosterone oenanthate ester andhydroxyprogesterone caproate by sensory, and chromatographic assessments. Only lipophilic Corynebacteriumspp(C. jeikeium and C. macginleyi ) and Staphylococcus capitisisolates were able to metabolize testosterone and hydroxy progesterone esters, with malodorous metabolites from the former only.Quantification of the yield of conversion of substrates into metabolites by the action of C. jeikeium was carried out using gas chromatography/mass spectrometryGC/MS. The odourous metabolites are suspected to be Androstadienone and 5-α-dihydrotestosterone, based on mass spectra and previously reported data. The effect of some selected material as potential deodorants on such metabolic activities was studied. In the absence of inhibitor, 99.6% of testosterone ester substrate was converted into metabolites. Ascorbic acid and orlistat dramatically inhibited testosterone ester metabolism allowing only 6.9 %, and 0.6 %conversion, respectively. While mastic gum allowed 84.3% conversion, no malodor was observed. These three components have the potentials to be used as deodorants. | ||||
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