Investigation of inflammatory cell count before and after surgical gingival melanin depigmentation (Histological and clinical study)

Elkot, Sarah Momtaz; Abo Zekry, Ahmed Kamal; amer, sheriferif abdelrahman

doi:10.21608/edj.2024.282818.3007

	Investigation of inflammatory cell count before and after surgical gingival melanin depigmentation (Histological and clinical study)
Egyptian Dental Journal
Volume 70, Issue 4 - Serial Number 3, October 2024, Page 3251-3257 PDF (575.56 K)
Document Type: Original Article
DOI: 10.21608/edj.2024.282818.3007
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Authors
Sarah Momtaz Elkot ¹; Ahmed Kamal Abo Zekry ²; sheriferif abdelrahman amer ¹
¹Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.
²Lecturer of oral and maxillofacial surgery, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt
Abstract
Background: Many individuals with hyperpigmented gingiva encounter esthetic problem which can be solved by surgical depigmentation procedures. As melanin acts as a scavenger for reactive oxygen species that attribute to the inflammation , depigmentation may unfortunately cause increase of inflammatory process. Aim: To investigate if the surgical melanin depigmentation could cause increased inflammation Subjects and methods: Seven individuals complaining from increased gingival melanin pigmentation have undergone surgical melanin depigmentation .Dummet Oral Pigmentation Index (DOPI) was the clinical parameter tested to investigate degree of melanin pigmentation. Inflammatory cell count was the histologic parameter to analyze number of inflammatory cells before and after depigmentation. Punch biopsy was taken at baseline and one month after depigmentation. Results: Both DOPI and inflammatory cell counts have significantly changed one month postoperative but there was no significant relation between these changes. Conclusion : Depigmentaion could possibly increase inflammation . Recommendations: More studies are needed to confirm direct proportion between depigmentation and inflammation.
Keywords
depigmentaion; inflammation; melanin


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