CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 47, Issue 2, December 2024, Page 1251-1262 PDF (929.12 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2024.297319.2162 | ||||
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| Authors | ||||
Akinpelu MORONKEJI   1; Temidayo D Adeniyi 2; Abiodun Oyeleke 3; Chuks M Igunbor4; Joy Olajumoke AYENI1; Toluwanimi Olanike ADELABI5; Adebimpe Moronkeji6
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| 1Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria. | ||||
| 2Department of Medical Laboratory Science, College of Health Sciences, University of Ilorin, Kwara State Nigeria. | ||||
| 3Department of Anatomy, Federal University Oye-Ekiti, Ekiti State, Nigeria | ||||
| 4Department of Medical Laboratory Science, Achievers University Owo, Ondo State, Nigeria | ||||
| 5Department of Medical Laboratory Science, Faculty of Allied Health Sciences University of Medical Sciences Ondo, Nigeria. | ||||
| 6Department of Medical Laboratory Science, Elizade University Ilara Mokin, Ondo State Nigeria. | ||||
| Abstract | ||||
| Pharmaceuticals typically induce toxicity in the liver and kidney, which are primary control mechanisms for maintaining bodily homeostasis and are more vulnerable to xenobiotics. Cymbopogon citratus (West Indian lemon grass) is used in traditional medicine globally for a variety of medicinal purposes. This study aimed to determine the therapeutic effectiveness of a methanolic leaf extract of C. citratus against NSAID-induced hepatorenal toxicity in adult Wistar rats (Rattus norvegicus domestica). Twenty rats weighing 180–220g were randomly assigned to four groups of five rats each. The unexposed control rats (Group 1) were administered distilled water, while the NSAID-exposed rats (Group 2-4) received Diclofenac at 5mg/kg/BW. While rats in Group 2 were untreated, rats in Groups 3 and 4 were treated with methanolic leaf extracts of C. citratus at 100mg/kg/BW and 200mg/kg/BW, respectively. Treatment with the methanolic extract of C. citratus modulates TNF-α and IL-10 expression (P<0.05) and ameliorates cellular alterations in the kidneys and liver of treated rats compared to the untreated group. This study established the efficacy of Cymbopogon citratus as a hepatorenal protector by considerably ameliorating the adverse effects of diclofenac-induced hepatorenal toxicity. | ||||
| Keywords | ||||
| cytokines; health; phytochemicals; Rats; toxicity | ||||
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