The Impact of Moringa oleifera and Azadirachta indica (neem) Leaves Ethanolic Extract on Streptozotocin Induced Diabetes Rats | ||||
| مجلة الاقتصاد المنزلي | ||||
| Volume 40, Issue 2, June 2024, Page 97-124 PDF (956.83 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jhe.2024.385869 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Sahar A. Abdel-Aziz1; Azza M. Baghdadi2 | ||||
| 1Department of Nutrition and Food Sciences, Food Industries and Nutrition Institute, National Research Centre, Cairo, Egypt | ||||
| 2Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia | ||||
| Abstract | ||||
| Diabetes mellitus (DM), especially Type 2, is a worldwide health issue marked by elevated insulin and blood glucose levels. The study aims to explore the impact of Moringa oleifera (MLE) and/or Neem leaves (NLE) ethanolic extract on streptozotocin (STZ) induced diabetes rats. Fifty-Six adult male albino rats were utilized in the study. The rats were split into seven groups as follow: group (1) served as normal, non-diabetic control (ND), while groups two to seven were induced into a diabetic state by intraperitoneal (ip) injection of STZ (40 mg/kg BW). Group two was diabetic rats with no treatment as positive control (D); group three and four received oral MLE at concentrations 250 and 500 mg/Kg, respectively. Groups five and six were given oral NLE at concentrations 250 and 500 mg/Kg, respectively. Finally, group seven comprised diabetic rats administered with a combination of MLE and NLE at concentration 250 mg/kg from each extract. After four experimental weeks, body weight, feed consumed were recorded, fasting serum insulin, glucose, lipid profile and endogenous antioxidant markers were determined. Results showed remarkable (P≤0.05) reduction in Feed Efficiency ratio (FER) and percentage of body weight gain (BWG %) in group D rats in comparison to ND rats. Additionally, findings revealed that diabetic rats in group (D) exhibited a considerable (P<0.05) reduction in serum insulin, endogenous antioxidants markers and HDL, while showed notable (P<0.05) increment in serum glucose, malondialdehyde and lipid profile parameters except HDL contrasted with ND rats. Oral administration of MLE, NLE and their combination led to remarkable (P<0.05) enhancement on all mentioned parameters. Furthermore, oral administration of MLE and NLE attenuated and ameliorated the histopathological adverse alteration that markedly detected in liver and pancreas tissues in D rats compared to ND rats. Conclusion: The moringa and Neem leaves ethanolic extract exhibited a hypoglycemic effect in STZ-induced diabetic rats. | ||||
| Keywords | ||||
| Moringa oleifera - Azadirachta indica; Diabetes; Hypoglycemic activity | ||||
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