PREPARATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES PHOSPHOLIPID COMPLEX LOADED WITH FENTICONAZOLE NITRATE FOR TOPICAL MANAGEMENT OF CANDIDA ALBICANS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 47, Issue 2, December 2024, Page 823-835 PDF (1.13 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2024.314224.2244 | ||||
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| Authors | ||||
Sarmad Dheyaa Noori  1; Hussein Hamed Hayal2; Hayder Hammoodi Mohamed3; Amira Amin4
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| 1Department of pharmaceutical chemistry, College of Pharmacy, Al-Ayen University | ||||
| 2Department of Pharmacognosy, College of Pharmacy, Al-Ayen Iraqi University | ||||
| 3Department of Pharmacy, Mazaya University College, Thi-Qar, Iraq | ||||
| 4Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damnhour University | ||||
| Abstract | ||||
| The current investigation aimed for loading Fenticonazole nitrate (FTN), an antifungal agent with low aqueous solubility, into solid lipid nanoparticles (SLNs) phospholipid complex for management of candida albicans topically. Fenticonazole nitrate is an antifungal medication which has substantial first pass metabolism results in low oral bioavailability. In order to prevent oral complications, the production of SLNs-phospholipid complex for improving Fenticonazole nitrate topical distribution was the focus of this study. By using a 21.31 full factorial design and different solid lipids and surfactants, SLNs formulas were created. SLNs phospholipid complex were fabricated applying thin film hydration method. SLNs phospholipid complex were evaluated with regard to entrapment efficiency percent (EE%), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). Further explorations were conducted on the optimum formulation. Utilizing Design Expert® software, the optimum formula (F2) was determined, revealing ZP of -23.50±1.11 mV, PDI of 0.41±0.005, PS of 137.05±0.45nm, and EE% of 77.44±0.94%. Further, the optimum formula showed spherical SLNs without aggregation under transmission electron microscope evaluation. In-vitro release study showed that the optimum formula was released more rapidly than FTN suspension. In addition, during storage the optimum formula was stable. The histological investigation verified the safety of the optimum SLNs. | ||||
| Keywords | ||||
| Fenticonazole nitrate; candida albicans; factorial design; solid lipid nanoparticles; histopathological study | ||||
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