ALLEVIATING REPRODUCTIVE DYSFUNCTION OF LEAD ACETATE IN MALE RAT: THE ROLE OF CURCUMIN AND METFORMIN | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 47, Issue 2, December 2024, Page 1263-1272 PDF (910.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2024.308078.2216 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Muhsin S.G Al Moziel 1; Abbas Abdulrazzaq Khudhair  2; Mohammed Azeez Qathee 3
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| 1College of Pharmacy /University of Basrah Verified email at uobasrah.edu.iq | ||||
| 2Department of clinical laboratory science, College of Pharmacy, University of Basrah, Basrah, Iraq. | ||||
| 3Department of Animal Production Techniquies,Technical Agricultural College of Mosul, Northern Technical Universitry | ||||
| Abstract | ||||
| Abstract To evaluate the ameliorative consequences of curcumin and metformin or their combination on lead reproductive toxic effect, 30 male Wister rats divided in to five groups as follow: Group 1 negative control. Group 2 lead acetate (50mg\kg B.W) orally for 6 weeks. Group 3 treated with same lead dose and curcumin (400mg\kg B.W) orally for 6 weeks. Group 4 treated with same lead dose and metformin (30mg\kg B.W) orally for 6 weeks and Group 5 treated with same lead dose and combination of curcumin with metformin (400mg\kg and 30mg\kg B.W) orally for 6 weeks respectively. With completion of study duration, all animal sacrificed, blood, serum sample obtained for hormonal evaluation along testes tissue for histopathological study. Result shows an improvement of hormonal levels and alleviation of structural changes induced by lead with curcumin and\ or metformin thus protective reproductive function achieved, also noted that curcumin produce better effect than metformin. | ||||
| Keywords | ||||
| Keywords: Curcumin; Metformin; Lead acetate | ||||
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