Correlation of Cytokines with Thyroid Hormones and Autoantibodies in Thyroid Autoimmune Diseases | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 12, Volume 34, Issue 1, January 2025, Page 99-109 PDF (902.79 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2024.322552.1344 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ali Razzaq R. Hussein  1; Khamael A.M Al-challabi2; Wurood K. Abed3; Haider A. Mahdi4; Anwer N. Al-Hatimy4
| ||||
| 1Directorate of Education in Al-Najaf, Ministry of Education, Al-Najaf, Iraq | ||||
| 2Al-Furat Al-Awsat University, Al-Najaf, Iraq | ||||
| 3Faculty of Medical Science, Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Al-Najaf, Iraq | ||||
| 4Al-Najaf Health Directorate, Iraqi Ministry of Health, Al-Najaf, Iraq | ||||
| Abstract | ||||
| Background: The autoimmune thyroid diseases (AITDs), like hyperthyroidism Graves' Disease (GD) and hypothyroidism Hashimoto's Thyroiditis (HT), are common occurrence autoimmune disease associated with thyroid hormones and immunity (autoantibodies and cytokine like IL-27 and IL-1β) disturbance. Objective: The aim of current study is to study and determine the relation of IL-27 and IL-1β cytokines with thyroid hormones and autoantibodies. Methodology: 150 participants in total (50 GD, 50 HT, and 50 control) all between the ages of 20 and 60 were attending Al-Sader Teaching Hospital in Al-Najaf. The ELISA kits were used to measure levels of IL27 and IL1β (MyBioSource, USA), and levels of thyroid hormones fT3, fT4, TSH (Elabscience firm, USA), whereas autoantibodies (TR Ab, TPO Ab, and Tg Ab) were measured by Cobas e411 instrument. Results: the patients were insignificantly more female; significantly older; and significantly had family history, body mass index, abnormal weight, urban residence than control. However, significantly (P=0.001) the levels of fT3 fT4 were high in GD and low in HT, and vice versa in TSH. The immunity including autoantibodies (TR Ab, TPO Ab, and Tg Ab) and Cytokine (IL27 and IL1β) were significantly (P=0.001) dysregulated and have increased level in GA and HT than control. The are positive correlation of IL27 and negative correlation of IL-1β with most parameters. Conclusion: AITDs resulted from immunity dysfunction and underlined by correlation of cytokine IL-27 and IL-1β with thyroid hormone and autoantibodies, however, TSH had positive correlation with IL-27 in HT and negative correlation with IL-1β in GD. | ||||
| Keywords | ||||
| Graves' disease; Hashimoto's Thyroiditis; IL-27; IL-1β; Autoantibodies | ||||
|
Statistics Article View: 202 PDF Download: 99 |
||||
