Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia
El-Deeb, A., Abd el motlb, E. (2011). Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia. EKB Journal Management System, 27(2), 107-111. doi: 10.1016/j.egja.2011.04.003
Alaa El-Deeb; Enas Abd el motlb. "Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia". EKB Journal Management System, 27, 2, 2011, 107-111. doi: 10.1016/j.egja.2011.04.003
El-Deeb, A., Abd el motlb, E. (2011). 'Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia', EKB Journal Management System, 27(2), pp. 107-111. doi: 10.1016/j.egja.2011.04.003
El-Deeb, A., Abd el motlb, E. Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia. EKB Journal Management System, 2011; 27(2): 107-111. doi: 10.1016/j.egja.2011.04.003

Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia

Egyptian Journal of Anaesthesia
Volume 27, Issue 2, April 2011, Page 107-111  XML PDF (411.65 K)
DOI: 10.1016/j.egja.2011.04.003
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Authors
Alaa El-Deeb; Enas Abd el motlb
Abstract
Background
To find out the cost effective antiemetic drug combination as a prophylaxis against nausea and vomiting during regional anesthesia for cesarean section.
Methods
After the gaining of institutional ethical approval, 240 parturients scheduled for elective cesarean delivery under spinal anesthesia were randomly allocated to receive either 2 mg granisetron plus 8 mg dexamethasone (group II) IV immediately after clamping of the fetal umbilical cord or 2 mg midazolam plus 8 mg dexamethasone (group III) IV or placebo (group I).
Results
The use of rescue antiemetic medication, which indicates either vomiting or severe nausea, in the post delivery period intraoperatively was 37%, 14%, 23% in group I, II and III, respectively. These values are significantly less than the corresponding values during the first 24 h after surgery which was 20%, 7%, 13%, respectively. No clinically serious adverse events were observed in any of the groups.
Conclusion
The prophylactic use of a granisetron/dexamethasone combination is better than midazolam/dexamethasone for reducing nausea and vomiting in patients during and after spinal anesthesia for cesarean section.
Keywords
cesarean section; Nausea; Vomiting; Granisetron; midazolam
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