Dexmedetomidine versus Nefopam for the management of post-spinal anesthesia shivering: A randomized double-blind controlled study | ||||
| Egyptian Journal of Anaesthesia | ||||
| Volume 31, Issue 4, October 2015, Page 315-320 PDF (603.69 K) | ||||
| DOI: 10.1016/j.egja.2015.06.004 | ||||
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| Author | ||||
| Sameh Mohammed Osman | ||||
| Abstract | ||||
| Background This study is designed to evaluate the relative efficacy of intravenously administered dexmedetomidine and nefopam for control of intraoperative shivering following spinal anesthesia. Materials and methods A prospective, randomized, double-blind, controlled study was conducted on 100 ASA grade I and II patients of either sex, aged 18–60 years, scheduled for elective lower abdominal and lower limb surgeries, under spinal anesthesia. Patients who developed post-spinal anesthesia shivering of grade 3 or 4 were included in the study, and randomly allocated to one of two groups, group D ( = 50), received Dexmedetomidine in a dose of 0.5 μg/kg diluted in 10 ml isotonic saline slowly I.V. (one minute duration), and group N ( = 50), received Nefopam in a dose of 0.15 mg/kg diluted in 10 ml isotonic saline slowly I.V. (one minute duration) when shivering was observed. Time taken for control of shivering, response rate, recurrence rate, hemodynamics, time to first request of rescue analgesic, one-patient cost and adverse effects were recorded. Results The time taken for control of shivering was statistically significantly shorter in Nefopam group (group N) compared with dexmedetomidine group (group D). The average time taken for disappearance of shivering was 2.35 ± 0.67 min in group N compared with group D (4.63 ± 1.19 min) ( = 0.041). Patients with incomplete response were more in group D (two patients in group D compared with nil in group N), but not statistically significant and recurrence rate was one patient in group D compared with nil in group N. Time to first request to rescue analgesic was significantly prolonged in group N (351.24 ± 19.71 min) compared with group D (192.63 ± 9.08 min). One-patient cost was significantly lesser in group N (about two £/patient) compared with group D (about 168 £/patient). Adverse effects such as bradycardia, hypotension and sedation were observed in Dexmedetomidine group, while pain at injection was noted in Nefopam group. Conclusion Nefopam is better as compared to dexmedetomidine for control of intraoperative shivering under spinal anesthesia due to its rapid onset, higher response rate, no sedation, lesser hemodynamic alterations, lesser requirements of rescue analgesics and lesser costs. | ||||
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