Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit
Deshpande, P. (2016). Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit. EKB Journal Management System, 32(1), 137-142. doi: 10.1016/j.egja.2015.08.003
Puja Deshpande. "Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit". EKB Journal Management System, 32, 1, 2016, 137-142. doi: 10.1016/j.egja.2015.08.003
Deshpande, P. (2016). 'Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit', EKB Journal Management System, 32(1), pp. 137-142. doi: 10.1016/j.egja.2015.08.003
Deshpande, P. Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit. EKB Journal Management System, 2016; 32(1): 137-142. doi: 10.1016/j.egja.2015.08.003

Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit

Egyptian Journal of Anaesthesia
Volume 32, Issue 1, January 2016, Page 137-142  XML PDF (423.41 K)
DOI: 10.1016/j.egja.2015.08.003
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Author
Puja Deshpande
Abstract
Background
Children undergoing different surgical procedures and requiring postoperative ventilation need intense analgesia and sedation. This was done using opioids and benzodiazepines with their common side effects as respiratory depression and prolonged sedation.
Aim of the study
To study the efficacy of sedation and time taken form stopping the infusion to extubation using low dose of dexmedetomidine compared with fentanyl sedation in post-operative Pediatric surgical Intensive Care Unit (PICU).
Patients and Methods
A randomized double-blind study involving 50 children undergoing different surgical procedures was performed. The patients were equally divided into two groups, each including 25 patients. One group sedated with fentanyl at 1 μg/kg/h (Fen Group) and the other group sedated with dexmedetomidine at 0.3 μg/kg/h (Dex Group) for 18 h post-operatively with intermittent rescue fentanyl 0.5 μg/kg bolus in the 2 groups as required during endotracheal suctioning. The depth of sedation was assessed using the Ramsay sedation score, the tracheal suctioning score and pediatric intensive care unit sedation score. The time taken from discontinuation of infusion till extubation was recorded.
Results
All sedation scores in the fentanyl and dexmedetomidine groups were comparable. Hemodynamic parameters were comparable between the two groups. Average time (in minutes) required for extubation after stopping the infusions was 136.2 (±54.2 SD) in the Dex group compared with 341.4 (±125.4 SD) in the Fen group. The difference in mean time for extubation was statistically significant. Conclusions: Low dose dexmedetomidine provides adequate sedation for mechanically ventilated children and also early extubation as compared with fentanyl.
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