The Impact of ATIC (rs2372536) Polymorphism on Responsiveness to and Toxicity of Methotrexate (MTX) in Rheumatoid Arthritis | ||||
| Ain Shams Medical Journal | ||||
| Volume 75, Issue 3, September 2024, Page 692-699 PDF (372.24 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2024.313455.1299 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noha refaat Mohamed 1; Roushan Osama Ahmed Negeda  2; Mona Zaki3; Marwa Adham Almohamady4; fatma mohamed badr5; Dina Tharwat Ghanem 6
| ||||
| 1clinical pathology, faculty of medicine, ain shams university, cairo , egypt | ||||
| 2Clinical pathology department, Ain Shams University | ||||
| 3Clinical pathology department, Faculty of Medicine, Ain shams university, Cairo , Egypt | ||||
| 4Clinical Pathology, Ain Shams University | ||||
| 5internal medicine department, faculty of medicine, ain shams university, Cairo , Egypt | ||||
| 6Clinical pathology, Ain Shams University,cairo, Egypt | ||||
| Abstract | ||||
| Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by ongoing inflammation of the synovial membranes and chronic aggressive arthritis. Despite significant advances in RA treatment in recent years, the total remission rate remains concerning and once bone or joint tissue has been destroyed, it is so hard to return to its original status. Objective : The current study aimed to examine the impact of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) rs 2372536 C >G polymorphism on the responsiveness and toxicity of methotrexate treatment in Egyptian rheumatoid arthritis patients. Methods: This cross-sectional study was performed on 50 rheumatoid arthritis patients. They were selected within the Rheumatology department at Ain Shams University Hospitals from January 2022 to January 2023. The enrolled patients were categorized into two groups in accordance to their response to methotrexate treatment: responders and non-responders. Determination of ATIC gene (rs 2372536) polymorphism was done by real-time PCR for all participants. Results: After 3 months of methotrexate therapy, the enrolled patients were divided into 25 responders and 25 non-responders. ATIC gene rs 2372536 C >G showed a relationship to failure of response to methotrexate treatment in the recessive model [GG vs. (CC+CG)] (p = 0.018). Also, the G allele was substantially found more in the non-responders (p= 0.045). Our study found no significant association between ATIC gene rs 2372536 C >G s polymorphism and the toxicity related to MTX. Conclusion: Our results showed that ATIC gene rs 2372536 C >G polymorphism is linked to failure to react to methotrexate therapy in Egyptian rheumatoid arthritis patients but has no association with vulnerability to toxicity from the treatment. | ||||
| Keywords | ||||
| ATIC; methotrexate; polymorphism; rheumatoid arthritis | ||||
|
Statistics Article View: 164 PDF Download: 188 |
||||
