SPECTROPHOTOMETRIC DETERMINATION OF MELOXICAM IN PURE FORM AND ITS PHARMACEUTICAL PREPARATIONS VIA OXIDATIVE COUPLING REACTION | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 47, Issue 2, December 2024, Page 1049-1062 PDF (1.48 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2024.308806.2221 | ||||
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| Authors | ||||
Ali Mohammed Atiyah   1; Asmaa Ahmed Mohammed 2; Abdul Majeed Khorsheed Ahmed3
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| 1Department of Chemistry, College of Science, University of Kirkuk, Kirkuk, Iraq. | ||||
| 2Department of Chemistry, College of Education for Pure Sciences, University of Tikrit, Tikrit, Iraq. | ||||
| 3university of kirkuk | ||||
| Abstract | ||||
| A new sensitive, cheap, and simple spectrophotometric method was used for the determination of Meloxicam (MEL) by oxidative coupling reaction with metol in the presence of ferric chloride (FeCl3) in the basic medium. This reaction yields a distinct purple-colored product that is water-soluble and exhibits maximum absorbance at 628 nm when compared to a blank solution. The method has obeyed Beer's Law within the concentration range of 3.0 to 20 μg ml-1, characterized by a relative error ranging from -1.13% to 1.2% and a relative standard deviation of 0.96% to 1.55%, depending on the concentration level. Key analytical parameters were determined, including a molar absorptivity of 1.9959×104 L mol-1 cm-1, Sandell's sensitivity of 0.0176 μg cm-2, and a detection limit of 0.1959 μg ml-1. The developed method was successfully validated and applied to the quantification of MEL in pharmaceutical preparations. This study demonstrates that the spectrophotometric method is efficient, precise, and suitable for routine analysis of MEL in quality control. | ||||
| Keywords | ||||
| Loxim; Metol; Oxidative coupling; Spectrophotometric | ||||
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