Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma
Elsebaey, Y., ElSaid, A., Abdallah, A., Mohamed, M. (2025). Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma. EKB Journal Management System, 68(7), 165-173. doi: 10.21608/ejchem.2024.314787.10246
Yasmin Mustafa Elsebaey; Afaf Mohamed ElSaid; Ahmed Shehta Abdallah; Magdy Mohamed. "Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma". EKB Journal Management System, 68, 7, 2025, 165-173. doi: 10.21608/ejchem.2024.314787.10246
Elsebaey, Y., ElSaid, A., Abdallah, A., Mohamed, M. (2025). 'Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma', EKB Journal Management System, 68(7), pp. 165-173. doi: 10.21608/ejchem.2024.314787.10246
Elsebaey, Y., ElSaid, A., Abdallah, A., Mohamed, M. Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma. EKB Journal Management System, 2025; 68(7): 165-173. doi: 10.21608/ejchem.2024.314787.10246

Association of Lymphotoxin-α +252A/G, Tumor Growth Factor-β −509C/T and Tumor Necrosis Factor-α -308A/G Polymorphisms with Hepatocellular Carcinoma

Egyptian Journal of Chemistry
Volume 68, Issue 7, July 2025, Pages 165-173    PDF (499.26 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.314787.10246
Authors
Yasmin Mustafa Elsebaey* 1; Afaf Mohamed ElSaid2; Ahmed Shehta Abdallah3; Magdy Mohamed4
1Biochemistry,fucalty of science Ain shams university,Cairo, Egypt
2Consultant of Biochemistry, Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt
3Gastroenterology Surgical Center, College of Medicine, Mansoura University, Egypt
4Professor of Biochemistry , Faculty of Science, Ain Shams University, Cairo, Egypt
Abstract
Background: Hepatocellular carcinoma (HCC) risk factors could either be host-genetic or environmental relation. This study aimed to assess the correlation of the three biallelic polymorphisms of lymphotoxin-alpha (LT-α) +252A/G, tumor growth factor-beta 1 (TGF-β1) −509C/T and tumor necrosis factor-alpha (TNF-α) -308A/G with HCC development regardless chronic hepatitis C (CHC) infection. Methods: These polymorphisms were studied among 220 consecutive participants. They were patients with/without HCV-related HCC, and with HCC related to etiologies other than HCV, in addition to the controls. Results: No significant difference between CHC patients and healthy controls regarding the distribution of genotypes of LTα +252A/G, TGF-β1 −509C/T and TNF-α -308A/G was observed. Regardless CHC infection, LTα GG genotype [29.2%, OR =1.99, 95% CI (0.98-4.07), P=0.039], TGF-β CT/TT genotypes [38.3%, OR =2.08, 95% CI (1.0-4.3), P=0.029], and TNF-α AG genotype [(35%, OR=1.27, 95% CI (1.05-1.54), P=0.028)] were more frequent in HCC compared to Non-HCC patients. Moreover, these genotypes were significantly associated (P<0.05) with HCC severity including tumor late stages, high grades, large tumor size, lymph node invasion and distant metastasis. Conclusion: our results demonstrating that LT-α +252A/G, TGF-β1 −509C/T and TNF-α -308A/G might be risk factors for HCC incidence. LT-α GG genotype, TGF-β CT/TT genotypes and TNF-α AG genotype might be correlated with HCC severity and progression.
Keywords
HCC; SNP; LT-α; TGF-β1; TNF-α
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