Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity
Abdel-Mageed, S., Foda, E., Abdel-Azeez, E., Elazab, S. (2019). Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity. EKB Journal Management System, 76(2), 3572-3580. doi: 10.21608/ejhm.2019.39163
Samia Abdel-Hamid Abdel-Mageed; Eldesoky E. Foda; Emam Mohamed Abdel-Azeez; Seham Abdallah Elazab. "Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity". EKB Journal Management System, 76, 2, 2019, 3572-3580. doi: 10.21608/ejhm.2019.39163
Abdel-Mageed, S., Foda, E., Abdel-Azeez, E., Elazab, S. (2019). 'Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity', EKB Journal Management System, 76(2), pp. 3572-3580. doi: 10.21608/ejhm.2019.39163
Abdel-Mageed, S., Foda, E., Abdel-Azeez, E., Elazab, S. Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity. EKB Journal Management System, 2019; 76(2): 3572-3580. doi: 10.21608/ejhm.2019.39163

Increased Risk of Rheumatoid Arthritis-Related Pulmonary Disease as a Results of Serum Anticitrullinated Protein Antibody Positivity

The Egyptian Journal of Hospital Medicine
Article 25, Volume 76, Issue 2, July 2019, Page 3572-3580  XML PDF (843.98 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.39163
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Authors
Samia Abdel-Hamid Abdel-Mageed1; Eldesoky E. Foda2; Emam Mohamed Abdel-Azeez3; Seham Abdallah Elazab email 1
1Department of rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Department of Internal Medicine and Immunology and Allergy Center, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
3Department of Radiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: there is increasing evidence to indicate that autoimmunity as well as inflammatory reactions occur systemically before development of any clinical sign of joint disease in patients with anti–citrullinated protein antibody (ACPA)–positive rheumatoid arthritis (RA). Objective: The aim of the work was to investigate the potential predictive value of anti-ccp3 for interstitial lung disease association with RA and to discriminate RA patient who are at potential risk to develop methotrexate (MTX) induced pulmonary toxicity. Patients and methods: This cross-sectional study included a total of 50 RA patients who were diagnosed according to the 2010 American College of Rheumatology / the European League Against Rheumatism classification criteria for Rheumatoid Arthritis (ACR/EULAR 2010 criteria) for detection of pulmonary manifestations attending at Physical medicine, Rheumatology and Rehabilitation Outpatient Clinics of Al-Azhar University Hospitals. Results: there was statistically significant difference between patients with and without interstitial lung disease (ILD), in high-resolution computed tomography (HRCT) as regards to Tiffeneau-Pinelli index (FEV1/FVC ratio), except for FEV1/FVC between patients with and without ILD in HRCT, forced expiratory volume in first second (FEV1), and forced vital capacity (FVC) are often decreased because of the reduction in lung volume, but the FEV1- to-FVC ratio is maintained or increased in ILD. Conclusion: RA patients without chest symptoms should not be neglected, pulmonary function testing and HRCT should be done routinely to pick up early ILD cases.
Keywords
Rheumatoid Arthritis; pulmonary disease; PCPA
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