Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt
Abd El-Latif, A., NADA, E., Abdo, R., El Hamshary, M., Shaeer, K. (2017). Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt. EKB Journal Management System, 21(2), 75-84. doi: 10.21608/smj.2017.39254
Ashraf Ahmed Abd El-Latif; ESSAMELDIN ABDELAZIZ NADA; Ramadan Saleh Abdo; Manal El Hamshary; Kamal Shaeer. "Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt". EKB Journal Management System, 21, 2, 2017, 75-84. doi: 10.21608/smj.2017.39254
Abd El-Latif, A., NADA, E., Abdo, R., El Hamshary, M., Shaeer, K. (2017). 'Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt', EKB Journal Management System, 21(2), pp. 75-84. doi: 10.21608/smj.2017.39254
Abd El-Latif, A., NADA, E., Abdo, R., El Hamshary, M., Shaeer, K. Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt. EKB Journal Management System, 2017; 21(2): 75-84. doi: 10.21608/smj.2017.39254

Y-Chromosome Microdeletion Analysis in Infertile Men from Upper Egypt

Sohag Medical Journal
Article 9, Volume 21, Issue 2, July 2017, Page 75-84  XML PDF (95.04 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.39254
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Authors
Ashraf Ahmed Abd El-Latif1; ESSAMELDIN ABDELAZIZ NADAorcid 2; Ramadan Saleh Abdo3; Manal El Hamshary; Kamal Shaeer
1Department of Dermatology, Venereology and Andrology- Faculty of Medicine- Sohag University.
2DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university
3Department , of Dermatology, Venereology and Andrology , Faculty of Medicine- , Sohag University
Abstract
Objectives:To study the prevalence and patterns of Y-chromosome microdeletions in infertile men from Upper Egypt and to determine the relationship between Y-chromosome microdeletions with clinicalandlaboratoryfindings in these patients.
Design: Cross-sectionalstudy.
Patients: Infertile men (n = 210) and a control group of fertile men with normal semen analysis (n = 30).
Methods: Clinical evaluation, standard semen analysis according to the WHO guidelines (WHO, 2010)andserumlevels of reproductive hormones were evaluated. Multiplex PCR was done for detection of Y chromosome microdeletions.
Results:AZF deletions were present in 7.14% of infertile men (9.59% in azoospermic and 1.56% in oligo-zoospermic men) with no deletions in the fertile normo-zoospericmen.CompleteAZFc was the detected in 2.05% of azoospermicmen.PartialAZFc deletions were found in 5.7% of infertile men, with gr/gr deletion in 5.24% and b2/b3 deletion in 0.48%.There was no significant difference between patients with AZF deletions and azoospermic men without deletions as regards testicular volume and serum levels of FSH, LH, testosterone and prolactin.
Conclusions:Microdeletions of Y chromosome may play a role in pathogenesis of non-obstructive azoospermia. The testicular volumes as well as levels of FSH, LH, testosterone and prolactin were not correlated with the finding of Y chromosome microdeletions.
Keywords
Male infertility; Y chromosome microdeletion; AZF regions
Supplementary Files
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