Early luteotrophic effect of vaginally administrated Letrozole in ewes | ||||
| New Valley Veterinary Journal | ||||
| Volume 5, Issue 1, January 2025, Page 9-14 PDF (648.76 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/nvvj.2024.258164.1039 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mohamed Abdeldaiem 
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| New valley university | ||||
| Abstract | ||||
| Early luteotrophic effect of letrozole on sheep steroidogenic competency during metestrus and early diestrus period of cycle were studied. Suppression of aromatase activity result in decreased estrogen concentration in blood. Hindering preovulatory LH surge. Which arrest follicular development after state of dominance, Also delay emergence of next follicular wave. Yielding in synchronous large number of follicles with synchronous ovulation which is responsible for increased concentration of estradiol in plasma. After ovulation this large number of good size follicles will yield in increase number of corpora lutea with large number of lutein cells that is responsible for high di-estral progesterone concentrations. progesterone in turn increase blood perfusion to corpora lutea. Letrozole early luteotrophic potency were tested after application of letrozole based synchronization protocol, performed by placing intravaginal sponge containing 7.5mg letrozole for five days, followed by intramuscular injection of prostaglandin at onset of removal. Compared with standard GPG protocol. progesterone concentrations in blood were assayed during early luteal development. Application of five days letrozole synchronization protocol in ewe, yielded in increasing early luteal diameter (steroidogenic capacity, beside early luteal vascularization for letrozole group (20.06 ± 2.22) compared to GPG group (15.52 ± 2.04 ) conferred by doppler ultrasound evaluation of luteal tissue. Findings in current experiment enables us to report the potent early lutotrophic capacity of intravaginal letrozole implicated in a novel synchronization protocol in ewes. This enhances its opportunities in further application in synchronization protocols. | ||||
| Keywords | ||||
| Letrozole; Embryonic mortality; luteotrophic effect; Estrus synchronization; Ewe | ||||
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