1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.
Zedan, M., Shoman, M., Mohamed, M., Abdel-Rahman, H. (2025). 1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.. EKB Journal Management System, 6(1), 1-15. doi: 10.21608/odr.2024.336752.1044
Mohamed Nabil Zedan; Mai Elsayed Shoman; Mohamed Abdel-Aziz Mohamed; Hamdy Mohamed Abdel-Rahman. "1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.". EKB Journal Management System, 6, 1, 2025, 1-15. doi: 10.21608/odr.2024.336752.1044
Zedan, M., Shoman, M., Mohamed, M., Abdel-Rahman, H. (2025). '1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.', EKB Journal Management System, 6(1), pp. 1-15. doi: 10.21608/odr.2024.336752.1044
Zedan, M., Shoman, M., Mohamed, M., Abdel-Rahman, H. 1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.. EKB Journal Management System, 2025; 6(1): 1-15. doi: 10.21608/odr.2024.336752.1044

1,2,4-Triazolo[1,5-a]pyrimidines as significant scaffold in drug discovery.

Octahedron Drug Research
Article 1, Volume 6, Issue 1, January 2025, Page 1-15  XML PDF (719.52 K)
Document Type: Review Articles
DOI: 10.21608/odr.2024.336752.1044
View on SCiNiTO View on SCiNiTO
Authors
Mohamed Nabil Zedan email 1; Mai Elsayed Shoman2; Mohamed Abdel-Aziz Mohamed3; Hamdy Mohamed Abdel-Rahman4
1Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Portsaid University
2Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University.
3Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Egypt
4Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Egypt
Abstract
Over the years, 1,2,4-Triazolo[1,5-a]pyrimidine (TP) emerged as an important scaffold in medicinal chemistry due to its vast application in designing novel anticancer, antimicrobial, antiviral, antiparasitic, and CNS-modulating agents. Recently, publications of TP analogues with diverse biological activities have increased markedly. In this review, we focus on the most important applications of TP scaffold in medicinal chemistry.

TP scaffold has emerged as a prominent scaffold in developing promising anti-cancer agents acting on multiple oncoargets such as DNA damage repair system, signal transduction pathway, ubiquitin-proteasome pathway (UPP), epigenetic modification, tumor microenvironment (TME), and multidrug resistance (MDR). Also, TP analogues provide promising candidates for treating different central nervous system (CNS) diseases acting through inhibition of acetylcholine esterase or phosphodiestrase 2A (PDE2A) or by Stabilizing Microtubules. Moreover, it represents a good pharmacophore for developing different candidates that have been acting as potent anti-infectious diseases such as(antibacterial, antiparasitic, and antiviral agents) over the recent years.
Keywords
Triazolopyrimidine (TP); biological activity; medicinal chemistry; heterocyclic compounds
Statistics
Article View: 995
PDF Download: 118