Does Serum vitamin D affect disease activity, sleep disorders and quality of life in Systemic Lupus Erythematosus patients? | ||
| Kasr Al Ainy Medical Journal | ||
| Volume 29, Issue 2, December 2024, Pages 9-17 PDF (527.36 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/kamj.2024.338437.1017 | ||
| Authors | ||
| Amira Mohammad EL-sharkawy1; Souzan Ezzat Gado* 2; Wesam Salah Ibrahim3; Hanaa Samy EL-banna4 | ||
| 1Lecturer Rheumatology, Rehabilitation & Physical Medicine. Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| 2Associate professor Rheumatology, Rehabilitation &Physical Medicine. Faculty of Medicine, Tanta university . Egypt | ||
| 3Professor clinical pathology. Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| 4Associate professor Rheumatology, Rehabilitation & Physical Medicine. Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| Abstract | ||
| Background: Early detection of vitamin D deficiency in patients with Systemic Lupus Erythematosus (SLE) may prevent or reduce fatigue, sleep and quality of daily life impairment. Objectives: to assess vitamin D deficiency or insufficiency in SLE patients, and to correlate it with clinical disease activity, sleep and quality of life impairment. Methods: 80 SLE patients plus 40 healthy volunteers as a control group. Sleep quality assessed by Pittsburgh Sleep Quality Index; disease activity assessed by SLE Disease Activity Index 2000. Functional capacity assessed by health assessment questionnaire. Serum Vit D measured by ELISA. Results: Serum vitamin D (25-OH D) levels were significantly lower in SLE patients compared to controls (p = 0.02). The lowest vitamin D level was detected in SLE patients with lupus nephritis (p = 0.003). There was a significant difference in SLEDAI, PSQI, FACIT-F, HAQ and SLE-QoL scores between SLE patients with sufficient and insufficient/deficient vitamin D serum levels (p= 0.028, and 0.001). a significant negative correlation between serum vitamin D level with clinical disease activity, functional capacity, sleep and quality of life. Conclusion: Vitamin D may play an important role in the pathogenesis of SLE and could be a promising biomarker of SLE disease activity. | ||
| Keywords | ||
| Systemic Lupus Erythematosus; vitamin D; Sleep Quality Index (PSQI); vitamin D deficiency; Systemic Lupus Erythematosus Quality of Life (SLEQoL); Lupus nephritis | ||
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