New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency
Saleh, D., Al-Salami, B. (2024). New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency. EKB Journal Management System, 10(5), 153-162. doi: 10.21608/jbaar.2024.396372
Dania Mohammed Saleh; Bushra Kamel Al-Salami. "New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency". EKB Journal Management System, 10, 5, 2024, 153-162. doi: 10.21608/jbaar.2024.396372
Saleh, D., Al-Salami, B. (2024). 'New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency', EKB Journal Management System, 10(5), pp. 153-162. doi: 10.21608/jbaar.2024.396372
Saleh, D., Al-Salami, B. New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency. EKB Journal Management System, 2024; 10(5): 153-162. doi: 10.21608/jbaar.2024.396372

New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency

Journal of Bioscience and Applied Research
Volume 10, Issue 5, December 2024, Page 153-162  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/jbaar.2024.396372
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Authors
Dania Mohammed Saleh; Bushra Kamel Al-Salami email
Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq
Abstract
In this study, two series of compounds have been prepared based on azo compound 4-chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl)iazinyl) benzene sulfonamide (A1) which prepared by diazotization of 2-amino-4-chlorobenzen sulfonamide and 4-hydroxy -3-methoxy benzaldehyde (vanillic aldehyde). The new azo (A1) subsequently reacted with amine and sulfa drugs such as 4-bromoaniline, sulfanilamide, sulfadiazine, and sulfathiazole to form corresponding azo-azomethine compounds as a first series. The reaction of this new azo-azomethine with thioglycolic acid with the participation of zinc chloride afforded thiazolidinone (MO and MS) as a second series. The prepared materials have been diagnosed with elemental analysis and various spectroscopic methods, spectroscopic techniques, such as IR, 1HNMR, 13CNMR, and Mass. All the new compounds were evaluated for their antioxidant using the free radical scavenging (DPPH) method. The antibacterial activities were studied in in-vitro as opposed to gram-positive (staphylococcus aureus) and gram-negative (Escherichia coli) by utilizing an agar diffusion process, at different concentrations to calculate MIC. Furthermore, the antifungal potential opposed to fungal strains such as candida albicans was studied and showed good to moderate activity.
Keywords
Amines; Antibacterial; Antioxidant; Azo; Azo-azomethine; Thiazolidine; Vanillic aldehyde
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