Assessment of Serum level of Cellular Communication Network Factor 3 in Rheumatoid Arthritis Patients and its Correlation to Disease Activity | ||||
| International Journal of Medical Arts | ||||
| Article 14, Volume 6, Issue 12, December 2024, Page 5231-5235 PDF (701.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2024.313540.2022 | ||||
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| Authors | ||||
Mahmoud Saeed Mohamed  1; Khaled Amer1; Ahmed S. Ezz 1; Mohamed Farouk Ibrahim Mosa2
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| 1Department of Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Rheumatoid arthritis [RA] is an autoimmune disease manifested by non-articular manifestations and articular ones that mostly affects synovial joints in a chronic manner. Aim of the work: The objective of this research was to evaluate the serum level of Cellular Communication Network Factor 3 [CCN3] in patients with RA and its association with activity of the disease. Patients and method: This case-control study involved ninety randomly selected cases over the age of eighteen, categorized into three groups: Group A consisted of thirty patients with rheumatoid arthritis in activity, Group B included thirty rheumatoid arthritis patients in remission, and Group C comprised thirty healthy individuals [Control]. All participants were collected from the Rheumatology & Rehabilitation outpatient clinic and inpatient at Bab El Sharia Al-Azhar University Hospital, Cairo. Results: CCN3 serum levels demonstrated a strong association with inflammatory markers and the Disease Activity Score [DAS28] in addition to with the Health Assessment Questionnaire [HAQ] score. The ROC curve analysis demonstrated a good discriminating power between active, remission and control groups with sensibility of 96.7% and an accuracy of 100.0% for distinguishing active from control groups. Conclusion: CCN3 serum levels show significant potential in differentiating between the active, remission, and control groups, indicating its promise as a biomarker for assessing activity of rheumatoid arthritis. | ||||
| Keywords | ||||
| Rheumatoid Arthritis; Cellular Communication Network; Disease Activity Score; Health Assessment Questionnaire; ESR | ||||
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