Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease
Kindy, S., Sarhan, A., Nasr, A., Zaitoun, M. (2020). Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease. EKB Journal Management System, 26(4), 582-589. doi: 10.21608/zumj.2019.13392.1241
Salma Meftah Kindy; Abdel-Mageed Mohamoud Sarhan; Ashraf Mohamed Nasr; Mohamed Moustafa Zaitoun. "Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease". EKB Journal Management System, 26, 4, 2020, 582-589. doi: 10.21608/zumj.2019.13392.1241
Kindy, S., Sarhan, A., Nasr, A., Zaitoun, M. (2020). 'Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease', EKB Journal Management System, 26(4), pp. 582-589. doi: 10.21608/zumj.2019.13392.1241
Kindy, S., Sarhan, A., Nasr, A., Zaitoun, M. Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease. EKB Journal Management System, 2020; 26(4): 582-589. doi: 10.21608/zumj.2019.13392.1241

Letrozole versus Clomiphene Citrate with metformin for Induction of Ovulation in Obese patients with Polycystic Ovarian Disease

Zagazig University Medical Journal
Article 7, Volume 26, Issue 4, July 2020, Page 582-589  XML PDF (784.4 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13392.1241
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Authors
Salma Meftah Kindy email 1; Abdel-Mageed Mohamoud Sarhan2; Ashraf Mohamed Nasr3; Mohamed Moustafa Zaitoun4
1Libya, Elmarkib University, Faculty of Medicine, Obstetrics & Gynecology
2Professor and Head of obstetrics and Gynaecology Faculty of Medicine - Zagazig University
3Professor of Obstetrics & Gynecology Faculty of Medicine - Zagazig University
4Lecturer of Obstetrics & Gynecology Faculty of Medicine - Zagazig University
Abstract
Background: the polycystic ovary syndrome (PCOS) is important cause of an ovulatory infertility and a notable proportion of women of reproductive age are affected. Different factors could result in different manifestations and many of these are related to predispositions. Objectives: The study was carried out to study the improvement of ovulation induction in obese patients with Polycyctic ovarian syndrome (PCOS). Subjects and methods: This is prospective clinical trial that was conducted in the infertility unit of Zagazig university Hospital on 120 patient suffering from PCOS were included in this study during the period from Actober 2018 to May 2019. This trial was designed to compare the improving induction of ovulation in obese females with Polycystic ovarian syndrome undergoing induction of ovulation by Clomid and Metformin (n=60) or Letrozole (n=60).Results: There was no significant statistical difference between Clomid and Metformin group and letrozole group in term of pregnancy rate, There was a significant statistical difference between Clomid and Metformin group and letrozole group in term of Size of dominant Graafian follicle (on day 11) (p=0.03) and the Size of dominant Graafian follicle (on day 13-14) (p=0.01).Conclusion Letrozole improves endometrial thickness and cervical mucosa and causes monofollicular ovulation but action of clomiphene citrate combined with metformin improved the ovulation and increased total number of follicles. Therefore, Letrozole can be used for the ovulation induction improvement in obese women having PCO
Keywords
Letrozole; Polycystic Ovarian Disease; Ovulation; Clomid
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