Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome
Gouda, W., Mageed, L., Wahba, E., Afify, M., Awad, M., Shalaby, S., Ezzat, W., Shaker, Y. (2017). Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome. EKB Journal Management System, 60(5), 957-964. doi: 10.21608/ejchem.2017.1510.1111
Weaam Gouda; Lamiaa Mageed; Esmat Wahba; Mie Afify; Mona Awad; Said Shalaby; Wafaa Ezzat; Yehia Shaker. "Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome". EKB Journal Management System, 60, 5, 2017, 957-964. doi: 10.21608/ejchem.2017.1510.1111
Gouda, W., Mageed, L., Wahba, E., Afify, M., Awad, M., Shalaby, S., Ezzat, W., Shaker, Y. (2017). 'Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome', EKB Journal Management System, 60(5), pp. 957-964. doi: 10.21608/ejchem.2017.1510.1111
Gouda, W., Mageed, L., Wahba, E., Afify, M., Awad, M., Shalaby, S., Ezzat, W., Shaker, Y. Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome. EKB Journal Management System, 2017; 60(5): 957-964. doi: 10.21608/ejchem.2017.1510.1111

Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome

Egyptian Journal of Chemistry
Article 20, Volume 60, Issue 5, October 2017, Page 957-964  XML PDF (983.02 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2017.1510.1111
View on SCiNiTO View on SCiNiTO
Authors
Weaam Goudaorcid 1; Lamiaa Mageed1; Esmat Wahbaorcid 1; Mie Afifyorcid 1; Mona Awad2; Said Shalaby3; Wafaa Ezzat4; Yehia Shaker email orcid 1
1Biochemistry Department, National Research Centre (NRC), Giza-Egypt
2Department of Clinical Pathology , National Research Centre, Giza, Egypt
3Department of Complementary Medicine, National Research Centre, Giza, Egypt
4Department of Internal Medicine, National Research Center, Giza, Egypt
Abstract
Background: Glucose intolerance, insulin resistance, hypertension, visceral obesity, and ‎dyslipidemia are the major components of metabolic syndrome (MS).‎
Aim: To evaluate the association between serum SHBG and IGF-1 levels and the risk of ‎MS. Furthermore, to determine the correlations between SHBG and IGF-1 and the main ‎components of MS.‎
Subjects and Methods: A total of 402 subjects with and without MS were enrolled in ‎this study (MS=156, Non-MS=246) aged > 18 years. The age, height, weight, BMI, HC, ‎WC, and incidence of diabetes, hypertension and dyslipidemia of all cases were recorded. ‎The collected serum samples were used to assess lipid profile, glucose and insulin levels. ‎The levels of LDL-cholesterol were calculated using Friedewald’s formula. Insulin ‎resistance was measured (as HOMA score). The levels of serum SHBG and IGF-1 were ‎measured using Elisa technique.‎
Results: A positive relationship between SHBG and MS was detected , ‎however no such correlation was observed concerning IGF-1. There were ‎positive correlations between SHBG and main components of MS; with insulin, HOMA-‎index, TC, TG and HDL . Conversely, IGF-1showed negative correlations. Finally, SHGB was ‎more sensitive (63.5%), accurate (61.9%) than IGF-1 (51.9%), accuracy ‎‎(59%) .‎
Conclusion: Our study reveals that lower SHBG is more strongly associated with ‎metabolic syndrome and its main components than lower IGF-1. SHBG could be the ‎essential driver of these relations, conceivably reflecting its association with insulin ‎sensitivity, however, more studies are required to confirm this relationship.‎
Keywords
Key words: Metabolic syndrome (MS); Sex hormone-binding globulin (SHBG); Insulin ‎like growth factor-1 (IGF-1); Insulin resistance(IR)
Statistics
Article View: 723
PDF Download: 425