Review on Analytical Methods for Determination of Lamivudine, Tenofovir disoproxil fumarate and Efavirenz in different matrices.

Khashaba, Bardees Abdelmonem; Fawzy, Michael Gamal; Hadad, Ghada M.; Ibrahim, Elsayed A

doi:10.21608/rpbs.2024.342491.1344

	Review on Analytical Methods for Determination of Lamivudine, Tenofovir disoproxil fumarate and Efavirenz in different matrices.
Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 1, 2024, Page 250-254 PDF (243.99 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2024.342491.1344
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Authors
Bardees Abdelmonem Khashaba ¹; Michael Gamal Fawzy ¹; Ghada M. Hadad ²; Elsayed A Ibrahim ³
¹Pharmaceutical Chemistry Department, Egyptian Russian University, Badr City, Egypt.
²Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
³Analytical Chemistry Department, Faculty of pharmacy, Suez Canal University, Ismailia, Egypt.
Abstract
Acquired Immunodeficiency Syndrome (AIDS) is a dangerous and fatal disease. Persons with AIDS can lead long, healthy lives if they receive early diagnosis, appropriate medical care, and medication. The combination of HIV medications is known as antiretroviral therapy (ART) is used to reduce transmission and stop the development of AIDS. This article is made for presenting a mini-review of different analytical methods for determination of some antiviral drugs namely lamivudine (LAM), tenofovir disoproxil fumarate (TDF) and efavirenz (EFA) either in pharmacopeia or not, in order to provide other researchers with up-to-date knowledge of the analytical techniques applied to determine the previously mentioned drugs either alone or combined with other antiretroviral agents. This article also includes essential data about the cited drugs, involving physical and chemical characteristics, as well as its pharmacological actions. The collected methods in this mini review include pharmacopeia, chromatographic (HPLC, TLC and UPLC), spectrophotometric and electrochemical methods. All methods are validated according to ICH.
Keywords
Analytical methods; Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate


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