ANTICANCER EFFECTS OF TOW TRADITIONAL DRINKS HIBISCUS (Hibiscus sabdariffa LINN) AND LIQUORICE (Glycyrrhiza glabra) | ||||
| Zagazig Journal of Agricultural Research | ||||
| Article 11, Volume 46, Issue 1, January and February 2019, Page 115-122 PDF (560.64 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjar.2019.40329 | ||||
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| Authors | ||||
Ahmed N. Elkattan  1; S. S. El-Saadany1; A. L. ElSayed1; A. M. Gomaa1; J. Abdalmuneim2
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| 1Biochem. Dept., Fac. Agric., Zagazig Univ., Egypt | ||||
| 2Fac. Vet., Zagazig Univ., Egypt | ||||
| Abstract | ||||
| Breast cancer (MCF-7), as well as liver cancer (HepG2), were the leader among new cancer cases. The objective of this study is to assess the viability percentage of tow traditional drinks (hibiscus and liquorice extracts) toward human breast and liver cancer cell lines at different concentrates from 250 to 5000 μg/ml in hibiscus extract and from 50 to 3000 μg/ml in liquorice extract. The viability percentage of hibiscus on breast and liver cancer cell lines were 86.9% and 84.7% at 5000 μg/ml, respectively. The IC50 of the hibiscus extract were 18478.6 μg/ml and 16159 μg/ml breast and liver cancer. In addition, the viability percentage of liquorice extract on breast and liver cancer cell lines were determined. Results revealed that liquorice extract has possessed high anticarcinogenic properties it was zero (%) at 3000 μg/ml for breast cancer and 5% for liver cancer at same concentration, the IC50 was 491.7 μg/ml in breast cancer and was 125 μg/ml in liver cancer cell line. DNA damage was determined to detect oxidative DNA damage in HepG2 cell line. This enhances the role of these traditional drinks especially liquorice as anti-cancer agents. | ||||
| Keywords | ||||
| Breast cancer (MCF-7); liver cancer (HepG2); traditional drinks; Hibiscus sabdariffa linn; liquorice (Glycyrrhiza glabra) | ||||
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