The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan
Badawy, A., El-Sayed, N., Mohamed, O., Nassar, S., Osman, M. (2024). The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan. EKB Journal Management System, 29(2), 61-69. doi: 10.21608/egyjnm.2024.333342.1108
Ahmed Mohamed Badawy; Nahla Dessoki El-Sayed; Omnia Alaa Mohamed; Sara Ayman Nassar; Mohammed Omar Osman. "The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan". EKB Journal Management System, 29, 2, 2024, 61-69. doi: 10.21608/egyjnm.2024.333342.1108
Badawy, A., El-Sayed, N., Mohamed, O., Nassar, S., Osman, M. (2024). 'The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan', EKB Journal Management System, 29(2), pp. 61-69. doi: 10.21608/egyjnm.2024.333342.1108
Badawy, A., El-Sayed, N., Mohamed, O., Nassar, S., Osman, M. The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan. EKB Journal Management System, 2024; 29(2): 61-69. doi: 10.21608/egyjnm.2024.333342.1108

The value of Tc-99mMDP bone scan in assessment of renal functions in urinary tract neoplasm patients after chemotherapy compared to Tc-99mDTPA renal scan

Egyptian Journal Nuclear Medicine
Volume 29, Issue 2, December 2024, Page 61-69  XML PDF (276.49 K)
Document Type: Original Paper, Diagnostic NM
DOI: 10.21608/egyjnm.2024.333342.1108
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Authors
Ahmed Mohamed Badawy email orcid 1; Nahla Dessoki El-Sayed2; Omnia Alaa Mohamed2; Sara Ayman Nassar2; Mohammed Omar Osmanorcid 2
1clinical oncology and nuclear medicine- faculty of medicine- Cairo university
2Department of Clinical Oncology and Nuclear Medicine, Cairo University, Egypt
Abstract
Abstract
Aim: our study investigates the use Tc-99mMDP for assessing GFR, split function and metastatic work-up in urinary tract neoplasm patients to replace separate Tc-99mDTPA and Tc-99mMDP studies with a single Tc-99mMDP study, thereby reducing cost, time and radiation exposure. Materials: Fifty adult patients with malignant urinary tract tumors underwent Tc-99mDTPA and Tc-99mMDP scans within one week. Tc-99mDTPA was administered at a 5 mCi for GFR measurement. For Tc-99mMDP, 5 mCi was used for dynamic renography followed by 15 mCi for post-3-hour whole-body imaging. Each kidney has its own ROI set around it, with a background area positioned underneath each kidney. The Gates' approach was used to calculate the GFR and split function. Results: the research showed a robust positive correlation between Tc-99mDTPA and Tc-99mMDP measurements: total GFR (r= 0.981, p < 0.001), LT kidney GFR, (r = 0.959, p < 0.001), RT kidney GFR (r = 0.980, p < 0.001), LT kidney split function (r = 0.951, p < 0.001) RT kidney split function (r = 0.951, p < 0.001). Conclusion: Tc-99mMDP can be an alternative to Tc-99mDTPA for evaluating renal function while conducting bone metastases surveys in patients with urinary tract malignancy with reduced cost and radiation exposure.
Keywords
GFR; split function; renal scan; bone scan; urinary tract neoplasms
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