Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles
Ebied, M., Zaghary, W., Amin, K., Hammad, S. (2017). Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles. EKB Journal Management System, 1(4), 216-227. doi: 10.21608/aprh.2017.4043
Mohammed Ebied; Wafaa Zaghary; Kamelia Amin; Sherif Hammad. "Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles". EKB Journal Management System, 1, 4, 2017, 216-227. doi: 10.21608/aprh.2017.4043
Ebied, M., Zaghary, W., Amin, K., Hammad, S. (2017). 'Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles', EKB Journal Management System, 1(4), pp. 216-227. doi: 10.21608/aprh.2017.4043
Ebied, M., Zaghary, W., Amin, K., Hammad, S. Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles. EKB Journal Management System, 2017; 1(4): 216-227. doi: 10.21608/aprh.2017.4043

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles

Journal of Advanced Pharmacy Research
Article 6, Volume 1, Issue 4, October 2017, Page 216-227  XML PDF (672.01 K)
Document Type: Research Article
DOI: 10.21608/aprh.2017.4043
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Authors
Mohammed Ebied1; Wafaa Zaghary1; Kamelia Amin2; Sherif Hammad* 2
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.
Abstract
Three series of ring-equivalent tricyclic benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles analogs were designed as bioisosteres and synthesized. The chemical structures of the synthesized agents were elucidated based on their spectral data and elemental analyses. The antimicrobial activity of some of the synthesized compounds was screened and only2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of Xwas1.85 mg/mL.
Keywords
Antimicrobial; Benzo[h]quinazolines; Benzo[h]quinolones; Naphthaleno[d]thiazoles
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