Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.
Sallam, D., El Hakim, I., ElKersh, A., El Sayed, M., Said, R. (2024). Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.. EKB Journal Management System, 19(2), 43-56. doi: 10.21608/geget.2024.406503
Dina Ebrahim Sallam; Ihab Zaki El Hakim; Amr Mohamed Fathy ElKersh; Mahy El Bassiouny El Sayed; Ragia Marei Said. "Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.". EKB Journal Management System, 19, 2, 2024, 43-56. doi: 10.21608/geget.2024.406503
Sallam, D., El Hakim, I., ElKersh, A., El Sayed, M., Said, R. (2024). 'Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.', EKB Journal Management System, 19(2), pp. 43-56. doi: 10.21608/geget.2024.406503
Sallam, D., El Hakim, I., ElKersh, A., El Sayed, M., Said, R. Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.. EKB Journal Management System, 2024; 19(2): 43-56. doi: 10.21608/geget.2024.406503

Dermatological Manifestations in Pediatric Patients with Chronic Kidney Disease.

GEGET
Volume 19, Issue 2, December 2024, Page 43-56  XML PDF (701.41 K)
Document Type: Original Article
DOI: 10.21608/geget.2024.406503
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Authors
Dina Ebrahim Sallamorcid 1; Ihab Zaki El Hakimorcid 1; Amr Mohamed Fathy ElKersh2; Mahy El Bassiouny El Sayed3; Ragia Marei Said email orcid 1
1Department of Pediatrics and Pediatric Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Faculty of Medicine, Ain Shams University, Cairo, Egypt.
3Department of Dermatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Introduction: Skin changes are common in chronic kidney disease (CKD) yet data on different skin lesions in children are limited.
Aim of the study: We aimed to screen dermatological manifestations in our pediatric CKD patients, and their relationships with CKD stage, dialysis modality, clinical and metabolic parameters.
Methods: A descriptive cross-sectional study on pediatric CKD patients, who were divided equally into group 1; CKD stage 5 on regular hemodialysis [online-hemodiafiltration (OL-HDF), high flux conventional hemodialysis (HF-HD), or a hybrid of both], and group 2; CKD stage 2-4 on conservative management.
Results: We included 70 pediatric CKD patients, with mean (±SD) age, CKD, and HD durations of 9.23 (±3.9), 3.92 (±2.73), and 2.67 (±1.94) years respectively. Eight (22.9%) patients were on OL-HDF, 7 (20%) on HF-HD, and 20 (57.1%) on a hybrid of both. Xerosis was considered the most frequent skin manifestations (78.6%), followed by pruritus (62.9%), and pallor 35.7%, meanwhile 6 (8.57%) patients had hair and nail abnormalities, where 4 (5.33%) had hair loss, one (1.4%) had albinisms, and one patient (1.4%) had onychomycosis. Skin, hair, and nail abnormalities didn’t differ significantly with CKD stages, HD modalities. Xerosis was associated with lower HD efficacy (Kt/V) and higher white blood cell count, while pruritis was associated with higher hemoglobin level.
Conclusion: Skin, nail, and hair abnormalities were not uncommon among our pediatric CKD patients, where xerosis and pruritis were the most common skin manifestations. Kt/V and total white blood cell count had related to xerosis, meanwhile hemoglobin level influenced pruritis.
Keywords
Chronic kidney disease; xerosis; pruritis; hemodialysis
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